The Kinetics of Reversible Hyaluronic Acid Filler Injection Treated With Hyaluronidase

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Margit L W JuhászEllen S Marmur

Abstract

Hyaluronidase is an enzyme capable of dissolution of hyaluronic acid (HA). There is a lack of evidence-based research defining time- and concentration-dependent reversal of HA filler using hyaluronidase. To explore the efficacy of different concentrations of hyaluronidase in digesting commercially available HA-based reversible fillers-Belotero Balance (BEL), Juvederm Ultra XC (JUVXC), Juvederm Ultra Plus (JUVX+), Juvederm Voluma XC (JUVV), Restylane-L (RESL), Restylane Silk (RESS), and Perlane/Restylane Lyft (RESLYFT). This was a blinded randomized study involving 15 participants. Participants received HA filler injection into their back, followed by no secondary injection, or injection with normal saline, 20 or 40 units of hyaluronidase. Using a 5-point palpation scale, the degradation of HA filler was monitored over 14 days. In the authors' study, there is a significant decrease in HA filler degradation using 20 and 40 units of hyaluronidase compared with no secondary injection or normal saline. There is no significant difference in HA filler dissolution when comparing 20 to 40 units of hyaluronidase. Lower concentrations of hyaluronidase may be just as effective as higher concentrations to degrade HA filler in situations whe...Continue Reading

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Citations

Apr 17, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Garrett T ShumateChristopher K Hee
Aug 21, 2018·European Journal of Medical Research·Bettina Alexandra BuhrenPeter Arne Gerber
Jan 14, 2020·Plastic and Reconstructive Surgery·Won LeeEun-Jung Yang
Dec 28, 2019·Ophthalmic Plastic and Reconstructive Surgery·Michael K PaapRona Z Silkiss
Mar 30, 2020·Plastic and Reconstructive Surgery·Won LeeEun-Jung Yang
Oct 10, 2018·Aesthetic Plastic Surgery·Christopher I Zoumalan
Mar 18, 2021·Clinical, Cosmetic and Investigational Dermatology·Seong Sung KwakWoo-Chan Son
Dec 8, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Sandy Zhang-NunesJill Foster
Aug 12, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Luiza Helena GremskiSilvio Sanches Veiga
Jun 12, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Shoaib Ugradar
Oct 6, 2021·Plastic and Reconstructive Surgery·Mobin Master

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