The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors

PloS One
Yanouk EpelboinCharlotte Corporeau


Oysters play an important role in estuarine and coastal marine habitats, where the majority of humans live. In these ecosystems, environmental degradation is substantial, and oysters must cope with highly dynamic and stressful environmental constraints during their lives in the intertidal zone. The availability of the genome sequence of the Pacific oyster Crassostrea gigas represents a unique opportunity for a comprehensive assessment of the signal transduction pathways that the species has developed to deal with this unique habitat. We performed an in silico analysis to identify, annotate and classify protein kinases in C. gigas, according to their kinase domain taxonomy classification, and compared with kinome already described in other animal species. The C. gigas kinome consists of 371 protein kinases, making it closely related to the sea urchin kinome, which has 353 protein kinases. The absence of gene redundancy in some groups of the C. gigas kinome may simplify functional studies of protein kinases. Through data mining of transcriptomes in C. gigas, we identified part of the kinome which may be central during development and may play a role in response to various environmental factors. Overall, this work contributes to a...Continue Reading


Aug 1, 1992·The Journal of Clinical Investigation·S K Wong, D L Garbers
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D L VeselyF E Friedl
Oct 1, 1995·General and Comparative Endocrinology·J E PoulosD L Vesely
Dec 1, 1995·Current Opinion in Cell Biology·A J Waskiewicz, J A Cooper
Oct 6, 1998·Annual Review of Biochemistry·D G HardieM Carlson
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Dec 19, 1998·Annals of Hematology·I HeideA Neubauer
Mar 17, 1999·Biochimica Et Biophysica Acta·P W Schenk, B E Snaar-Jagalska
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·G D PlowmanT Hunter
May 20, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C BerthelinM Mathieu
Jul 26, 2000·The Journal of Cell Biology·D K MorrisonV Cleghon
Oct 24, 2000·The Journal of Biological Chemistry·I GotohE Nishida
Dec 15, 2000·Oncogene·D R RobinsonS F Lin
Apr 18, 2001·Cellular Signalling·M Silberbach, C T Roberts
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Y Takei
Sep 11, 2001·Biochemical and Biophysical Research Communications·S L ChoiJ Ha
Sep 11, 2002·Developmental Biology·You-Seung KimMark F A VanBerkum
Oct 9, 2002·Trends in Biochemical Sciences·Gerard ManningSucha Sudarsanam
Dec 10, 2002·Science·G ManningS Sudarsanam
Mar 1, 2003·Nature Biotechnology·Matthias Mann, Ole N Jensen
Aug 28, 2003·Biology of the Cell·Amelia Portillo-LópezJosé Luis Stephano
Dec 19, 2003·Nucleic Acids Research·Alex BatemanSean R Eddy
Jan 20, 2004·Trends in Biochemical Sciences·David Carling
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sean CaenepeelGerard Manning
Feb 16, 2005·The Journal of Biological Chemistry·Takehiro Yamamoto, Norio Suzuki
Apr 7, 2005·Journal of Health Economics·Willard G ManningJohn Mullahy
Jun 16, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Barbara MarchiGabriella Gallo
Aug 18, 2005·Journal of Cell Science·Maosong Qi, Elaine A Elion
Sep 27, 2005·Biochimica Et Biophysica Acta·Nicole LaRonde-LeBlanc, Alexander Wlodawer

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