The kiss of death: interrupted by NK-cell close encounters of another kind

Trends in Immunology
S M WahlNiki M Moutsopoulos

Abstract

An intimate but deadly encounter between natural killer (NK) cells and transformed cells results in the delivery of cytotoxic molecules into tumor cells. New evidence reveals another intimate association, this time between NK cells and regulatory T cells, but this encounter opposes NK-cell tumoricidal activity. Through a contact-dependent mechanism involving transforming growth factor-beta, regulatory T cells provide an escape mechanism from NK-cell-mediated tumor surveillance.

References

Mar 26, 2003·Cytokine & Growth Factor Reviews·WanJun Chen, Sharon M Wahl
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Oct 1, 2004·Arthritis and Rheumatism·Ethan M Shevach
Jan 18, 2005·Current Opinion in Immunology·Jessica A HamermanLewis L Lanier
Jan 26, 2005·Trends in Immunology·Christopher A KlebanoffNicholas P Restifo
Jul 23, 2005·International Reviews of Immunology·Shimon Sakaguchi, Noriko Sakaguchi
Jul 26, 2005·Cytotherapy·H-G Klingemann
Aug 20, 2005·Immunology Letters·Lorenzo MorettaAlessandro Moretta
Oct 19, 2005·The Journal of Experimental Medicine·François GhiringhelliLaurence Zitvogel

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Citations

Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Gikas E KatsifisSharon M Wahl
Jul 10, 2010·Nature Reviews. Immunology·Richard A FlavellPaula Licona-Limón
Dec 14, 2011·Journal of Molecular Cell Biology·Dat Q Tran
Aug 25, 2011·Cellular and Molecular Life Sciences : CMLS·Alfonso Martín-FontechaHugh J M Brady
Dec 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Dermot S O'CallaghanKenneth J O'Byrne
Sep 27, 2008·The American Journal of Pathology·Maria I ChristodoulouHaralampos M Moutsopoulos
May 20, 2008·Current Opinion in Immunology·Niki M MoutsopoulosSharon M Wahl
Sep 16, 2006·Immunological Reviews·Sharon M WahlNiki Moutsopoulos
Aug 27, 2014·Cytokine & Growth Factor Reviews·Eric TuWanjun Chen
Sep 9, 2006·Journal of Leukocyte Biology·Natacha RalainirinaJacques Zimmer
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin GirouxClaude Perreault
Feb 11, 2020·Frontiers in Immunology·Ombretta MelaiuDoriana Fruci
Oct 8, 2020·International Journal of Molecular Sciences·Magdalena HuberMatthias Lauth
Dec 2, 2006·Current Opinion in Immunology·Sharon M Wahl

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