The Kluyveromyces lactis repertoire of transcriptional regulators

FEMS Yeast Research
Françoise BussereauM Bolotin-Fukuhara

Abstract

We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data.

References

Oct 25, 1996·Science·A GoffeauS G Oliver
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 1, 1997·Fungal Genetics and Biology : FG & B·R B Todd, A Andrianopoulos
Sep 24, 1998·European Journal of Biochemistry·E RamilM E Cerdán
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·K W TzungN Agabian
Sep 5, 2001·Molecular and Cellular Biology· Vik A, J Rine
Aug 7, 2003·Trends in Genetics : TIG·Balázs PappLaurence D Hurst
Nov 29, 1955·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D G WILD, C HINSHELWOOD
Nov 14, 2003·FEMS Yeast Research·Massoud Ramezani-RadGerd Gellissen
Dec 3, 2003·Molecular Genetics and Genomics : MGG·K MøllerL Olsson
Jan 22, 2004·FEMS Yeast Research·Francoise BussereauMonique Bolotin-Fukuhara
May 4, 2004·Molecular and Cellular Biology·Godefroid CharbonIsabelle Noël-Georis
May 4, 2004·Nature Genetics·Zhenglong GuWen-Hsiung Li
May 5, 2004·The Journal of Biological Chemistry·Bassel AkacheBernard Turcotte
Jul 2, 2004·Molecular Microbiology·Jure Piskur, Rikke B Langkjaer
Jul 2, 2004·Nature·Bernard DujonJean-Luc Souciet

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Citations

Sep 8, 2010·Journal of Industrial Microbiology & Biotechnology·Mónica Lamas-MaceirasAna Maria Rodríguez Torres
Sep 29, 2011·Canadian Journal of Microbiology·Nora Toth HervayYvetta Gbelska
Oct 3, 2012·BMC Genomics·Oscar DiasIsabel Rocha
Sep 1, 2009·Microbial Cell Factories·M Isabel González-SisoM Esperanza Cerdán
Mar 22, 2014·BMC Genomics·Richard B ToddRonald P de Vries
Jul 9, 2013·FEBS Letters·Ana M Rodríguez-TorresMaría A Freire-Picos
Feb 12, 2010·Yeast·Claudina Rodrigues-PousadaCatarina Pimentel
Jul 4, 2012·Fungal Genetics and Biology : FG & B·Andrea Walther, Jürgen Wendland
Feb 18, 2009·FEMS Yeast Research·Katarina BalkovaYvetta Gbelska
Oct 25, 2016·Canadian Journal of Microbiology·Nora Toth HervayYvetta Gbelska
Feb 2, 2019·Folia Microbiologica·Alexandra BencovaYvetta Gbelska
Aug 3, 2021·Frontiers in Microbiology·Ilaria CamponeschiMichele M Bianchi

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