PMID: 20127006Feb 4, 2010Paper

The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth

Oncology Reports
Hiromi SasakiSetsuro Komiya

Abstract

Polycomb group proteins control the transcriptional memory of cells by maintaining the stable silencing of specific sets of genes through chromatin modifications. Polycomb group protein complexes control gene repression through recruitment of histone deacetylase. This recruitment leads to trimethylation of Lys27 of histone H3 (H3K27). Histone H3K27 trimethylation is a property of stably silenced heterochromatin. EZH2 and BMI-1 are pivotal components of polycomb group protein complexes. Increased EZH2 levels have been found in several malignancies and reported as a molecular biomarker of poor prognosis. Similarly, BMI-1 has also been found to be associated with malignant transformation. In addition, inhibition of EZH2 or BMI-1 inhibits the growth of various types of malignancies. The expression of BMI-1 and EZH2 in human osteosarcoma has not been clearly determined. We examined the potential involvement of aberrant polycomb group protein expression in the pathogenesis of osteosarcoma. Real-time PCR revealed that expression of EZH2 in 143B, HOS, NOS-1 and Saos2 was increased compared to normal osteoblasts. BMI-1 was also up-regulated in 143B, HOS and NOS-1. Expression of EZH2 and BMI-1 were up-regulated in osteosarcoma patient bi...Continue Reading

Citations

Sep 2, 2011·Cell Death & Disease·H RichlyL Di Croce
Jul 14, 2012·PloS One·Hiroko NagaoSetsuro Komiya
Oct 22, 2013·Journal of the Neurological Sciences·Zhenyu WuYanyang Tu
Jul 18, 2014·Virchows Archiv : an International Journal of Pathology·Ryo ShibuyaMasanori Hisaoka
Apr 21, 2011·The Journal of Pathology·Hiroko NagaoTakao Setoguchi
May 18, 2021·Frontiers in Immunology·Jitian LiZhiping Guo

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