The Kölliker-Fuse nucleus orchestrates the timing of expiratory abdominal nerve bursting.

Journal of Neurophysiology
William H BarnettDaniel B Zoccal

Abstract

Coordination of respiratory pump and valve muscle activity is essential for normal breathing. A hallmark respiratory response to hypercapnia and hypoxia is the emergence of active exhalation, characterized by abdominal muscle pumping during the late one-third of expiration (late-E phase). Late-E abdominal activity during hypercapnia has been attributed to the activation of expiratory neurons located within the parafacial respiratory group (pFRG). However, the mechanisms that control emergence of active exhalation, and its silencing in restful breathing, are not completely understood. We hypothesized that inputs from the Kölliker-Fuse nucleus (KF) control the emergence of late-E activity during hypercapnia. Previously, we reported that reversible inhibition of the KF reduced postinspiratory (post-I) motor output to laryngeal adductor muscles and brought forward the onset of hypercapnia-induced late-E abdominal activity. Here we explored the contribution of the KF for late-E abdominal recruitment during hypercapnia by pharmacologically disinhibiting the KF in in situ decerebrate arterially perfused rat preparations. These data were combined with previous results and incorporated into a computational model of the respiratory centr...Continue Reading

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Jun 14, 2018·Physiology·Bruce G LindseyKendall F Morris
Sep 7, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel B ZoccalAna C Takakura
Mar 26, 2019·The Journal of Physiology·Samuel WittmanJonathan E Rubin
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Jun 17, 2020·Experimental Physiology·Michael George Zaki Ghali
Jul 6, 2020·The Journal of Physiology·Karine C FlorDaniel B Zoccal
May 13, 2020·Journal of Neurochemistry·Adrienn G VargaErica S Levitt
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Dec 5, 2019·Frontiers in Systems Neuroscience·Ioan OprisBrian R Noga
Nov 11, 2020·Journal of Cellular Physiology·Hao XingChun Jiang
Feb 5, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ryuji Sakakibara
Oct 15, 2020·Physiology·Barbara PalkovicAstrid G Stucke
Feb 24, 2021·Journal of Anatomy·Rosa L CoolenBertil F M Blok
Oct 15, 2020·Respiratory Physiology & Neurobiology·M DutschmannW I Furuya
Mar 31, 2021·Respiratory Physiology & Neurobiology·Ana C TakakuraThiago S Moreira
Apr 8, 2021·Journal of Neurophysiology·Jan-Marino RamirezErica S Levitt

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