The KSHV RNA regulator ORF57: target specificity and its role in the viral life cycle

Wiley Interdisciplinary Reviews. RNA
Carolin Vogt, Jens Bohne

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes ORF57, which enhances the expression of intron-less KSHV genes on multiple post-transcriptional levels mainly affecting RNA stability and export to the cytoplasm. Yet, it remains elusive how ORF57 recognizes viral RNAs and discriminates them from cellular messenger RNAs (mRNAs). Although one common binding motif on three separate KSHV RNAs has been described, most other lytic genes lack this sequence element. In this article we will review the sequence requirements for ORF57 to enhance RNA expression and discuss a model how ORF57 achieves specificity for viral RNAs. Finally, the role of ORF57 is integrated into the viral life cycle as a complex interplay with other viral and host factors and with implications for cellular gene expression.

References

Dec 1, 1995·Genes & Development·S Z Tarun, A B Sachs
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·R SunG Miller
Nov 7, 2001·Current Biology : CB·D GatfieldE Izaurralde
Oct 9, 2002·Nature·Malcolm J GardnerClaire M Fraser
May 13, 2003·Reviews in Medical Virology·Zhi-Ming Zheng
Aug 23, 2003·Trends in Biochemical Sciences·Bryan R Cullen
Jul 13, 2004·Trends in Biotechnology·Claes GustafssonJeremy Minshull
Dec 20, 2005·The Journal of Pathology·Thomas F Schulz
May 25, 2006·Cell Cycle·Andrew J BarberaKenneth M Kaye
Aug 1, 2006·Advances in Virus Research·Britt A Glaunsinger, Donald E Ganem
Nov 23, 2006·RNA Biology·Patricia Sanchez-Diaz, Luiz O F Penalva
Jun 19, 2007·Nature Reviews. Genetics·Jack D Keene
Sep 6, 2007·Nature Reviews. Molecular Cell Biology·Alwin Köhler, Ed Hurt
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Zsolt Toth, Thomas Stamminger
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Jianming Qiu, David Pintel
Mar 18, 2008·FEBS Letters·Tina GlisovicGideon Dreyfuss
Jun 3, 2008·Current Opinion in Structural Biology·Antoine CléryFrédéric H-T Allain
Feb 26, 2009·Cell·Melissa J Moore, Nick J Proudfoot
Apr 7, 2010·The Journal of Clinical Investigation·Don Ganem
Nov 27, 2010·Science·Rachel M Mitton-FryJoan A Steitz
Jun 1, 2011·PLoS Pathogens·Nicholas RenzetteTimothy F Kowalik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.