The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

Obesity
Marie FavennecOdile Poulain-Godefroy

Abstract

This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and the expression of KP enzymes in adipose tissue. Tryptophan and KP metabolite levels were measured in serum of individuals from the D.E.S.I.R. cohort (case-cohort study: 212 diabetic, 836 randomly sampled) and in women with obesity, diabetic or normoglycemic, from the ABOS cohort (n = 100). KP enzyme gene expressions were analyzed in omental and subcutaneous adipose tissue of women from the ABOS cohort, in human primary adipocytes and in monocyte-derived macrophages. In the D.E.S.I.R. cohort, kynurenine levels were positively associated with body mass index (BMI) (P = 4.68 × 10(-19) ) and with a higher HOMA2-IR insulin resistance index (P = 6.23 × 10(-4) ). The levels of kynurenine, kynurenic acid, and quinolinic acid were associated with higher BMI (P < 0.05). The expression of several KP enzyme genes (indoleamine 2,3-dioxygenase 1 [IDO1], kynureninase [KYNU], kynurenine 3-monooxygenase [KMO], and kynurenine aminotransferase III [CCBL2]) was increased in the omental adipose tissue of women with obesity compared to lean (P < 0.05), and their expression was induced by proinflammatory cytokines in human primary...Continue Reading

References

Nov 1, 1995·Bioscience, Biotechnology, and Biochemistry·K ShibataH Tsuge
Sep 24, 1998·Transplantation Proceedings·G MeyramovN Kocheryzkina
Aug 25, 2001·Journal of Neurochemistry·G J GuilleminB J Brew
Mar 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·D A ROSENJ S FRIEDENWALD
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 29, 2004·Free Radical Research·C M ForrestL G Darlington
Oct 25, 2007·Biochemical Society Transactions·A J SmithR A Smith
Nov 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gilles J GuilleminBruce J Brew
Feb 9, 2008·The American Journal of Clinical Nutrition·Erlend T AasheimThomas Bøhmer
Apr 9, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kazuo YamadaMikako Tsuchiya
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jörg C SchefoldPetra Reinke
Dec 17, 2009·Journal of Neuroinflammation·Ka Ka TingGilles J Guillemin
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Nov 1, 2011·Archives of Physiology and Biochemistry·Praveen Kumar MunipallyNaga Raju Turlapati
Nov 16, 2011·International Journal of Tryptophan Research : IJTR·Nady BraidyRoss Grant
Nov 26, 2011·Sub-cellular Biochemistry·Simonetta FrisoSang Woon Choi
Apr 19, 2012·The Journal of Biological Chemistry·Thérèse Hérvée MayiGiulia Chinetti-Gbaguidi
May 18, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Isabelle WolowczukOdile Poulain-Godefroy
Apr 12, 2013·Nature·Marta AmaralNigel S Scrutton
Sep 17, 2013·Circulation Research·Gaël BoriesGiulia Chinetti-Gbaguidi
Nov 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Julie LasselinLucile Capuron
Feb 26, 2014·Frontiers in Neuroscience·Brian M CampbellThomas Möller
May 1, 2013·Diabetes Management·Frank K HuynhMatthew D Hirschey
Jul 31, 2014·Cellular Microbiology·Victoria J Vieira-Potter
Sep 25, 2014·Obesity·Wei PerngEmily Oken
Sep 26, 2014·Metabolomics : Official Journal of the Metabolomic Society·Steven C MooreAmanda J Cross
Dec 6, 2014·Frontiers in Neuroscience·Jason C D NguyenTrisha A Jenkins

❮ Previous
Next ❯

Citations

May 18, 2016·Molecular Neurobiology·Leandro Ceotto Freitas LimaSérgio Henrique Sousa Santos
Jul 9, 2016·BMC Microbiology·Perrine BortolottiAudrey Le Gouellec
Mar 8, 2016·Diabetes/metabolism Research and Reviews·Jonathan M MudryHarriet Wallberg-Henriksson
Feb 7, 2018·Metabolic Syndrome and Related Disorders·Neila Hiraishi MallmannPritesh Lalwani
Nov 17, 2017·Biological Research for Nursing·Maureen GroerTeodor T Postolache
May 12, 2017·American Journal of Physiology. Renal Physiology·Laura V de VriesStephan J L Bakker
Aug 25, 2018·Journal of Internal Medicine·S DadvarJ L Ruas
Nov 9, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Jun-Jun LiuBernard Portha
Dec 1, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel A MurphyTamara B Harris
Jul 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louise A SwainsonJoseph M McCune
Nov 7, 2019·British Journal of Pharmacology·Micah G DonovanDonato F Romagnolo
Aug 15, 2020·Journal of Internal Medicine·R BaumgartnerD F J Ketelhuth
Sep 8, 2020·Molecular Neurobiology·Nady BraidyGilles J Guillemin
Jan 6, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel A MurphyUNKNOWN Health ABC Study
Jun 13, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vincent ChourakiSudha Seshadri
Aug 7, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M JennisP J Hornby
Apr 14, 2019·Molecular Psychiatry·Jonathan Savitz
Nov 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Gholamreza BidkhoriAdil Mardinoglu
Mar 21, 2017·Cellular and Molecular Life Sciences : CMLS·Ping SongMing-Hui Zou
Mar 9, 2019·Frontiers in Psychiatry·Eva Z ReininghausBernd Reininghaus
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Aug 29, 2020·Nature Reviews. Gastroenterology & Hepatology·Arpana GuptaEmeran A Mayer
Jul 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronNathalie Castanon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.