The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population

Molecular Nutrition & Food Research
Inka LindnerFrank Döring

Abstract

Enzymes of the medium-chain acyl-CoA synthetase (MACS) family catalyze the ligation of medium chain fatty acids with CoA to produce medium-chain-acyl-CoA. At least four members of the MACS gene family are clustered on human chromosome 16p12. Association studies in the Japanese Suita cohort of MACS polymorphisms and various phenotypes revealed the contribution of the Leu513Ser polymorphism in MACS2 to multiple risk factors of the metabolic syndrome. Here, we investigated the association between this polymorphism and different risk factors in the Caucasian Metabolic Intervention Cohort Kiel. Seven hundred and sixteen male subjects aged 45-65 years were recruited for a standard oral glucose tolerance test and the postprandial assessment of metabolic parameters after an oral metabolic tolerance test (oMTT; 1017 kcal, 51.6% fat, 29.6% carbohydrates, 11.9% protein). The MACS2 Leu513Ser polymorphism was determined by TaqMan-Assay in 705 subjects. Postprandial triglyceride levels following oMTT [area under the curve (AUC)] were significantly higher in subjects carrying the Ser allele compared to subjects homozygous for the Leu allele (1690 +/- 100 mg x h/dL versus 1514 +/- 39 mg x h/dL, p = 0.04). Significant differences between genoty...Continue Reading

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Citations

Feb 27, 2010·Journal of Psychiatric Research·Lavinia AthanasiuOle A Andreassen
Oct 28, 2015·European Journal of Haematology·Ramón MontesUNKNOWN Grupo de Trabajo de Patología Trombótica de la Sociedad Española de Trombosis y Hemostasia (SETH)
Jul 16, 2019·Nucleic Acids Research·Weiyu ZhangXinyi Lu
May 30, 2020·Prenatal Diagnosis·Toluwani E TaiwoRichard H Finnell

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