PMID: 6113550Jan 1, 1980

The lack of a pronounced preference of prenalterol for the beta-l-adrenoceptor subtype

Naunyn-Schmiedeberg's Archives of Pharmacology
N RohmH J Schümann

Abstract

The beta-sympathomimetic effect of prenalterol was investigated on the electrically driven left atrium as well as on the tracheal chain of the guinea pig. 1. On the atrium driven at 2 Hz prenalterol caused a positive inotropic effect with a pD2-value of 7.0 +/- 0.08 (N = 4). Compared to isoprenaline (1.0) its intrinsic activity amounted to 0.3. 2. On the tracheal chain prenalterol caused very little relaxation. Its intrinsic activity was virtually negligible when compared with those of fenoterol (1.0) or noradrenaline (1.0); it amounted to 0.07 only. 3. On the atrium the positive inotropic effect of prenalterol vanished after 1 hour of incubation. At this time the concentration-response curve for isoprenaline was shifted dose-dependently to the right. The pD2-value for isoprenaline was significantly diminished (P less than 0.001) by prenalterol, 10(-6)M, from 8.36 to 7.14. 4. Likewise, on the trachea prenalterol caused a pronounced, dose-dependent shift of the concentration-response curves for fenoterol as well as for noradrenaline to the right. 5. The results presented here show that on beta-adrenoceptors of the guinea pig prenalterol is acting like a partial agonist in the left atrium, but as full antagonist in the trachea.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
May 31, 1978·European Journal of Clinical Pharmacology·G JohnssonJ Wikstrand
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·D Reinhardt, J Wagner
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Citations

Oct 1, 1982·European Journal of Clinical Pharmacology·C G Löfdahl, N Svedmyr
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Feb 8, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roland SeilerBruno M Balsiger
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Metazoa
Dose-Response Relationship, Drug
Cavia porcellus
Novodrin
Myocardial Contraction
Dalzic
Prenalterol Hydrochloride
Norepinephrine Receptors

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.