The lack of association between the burden of monosodium urate crystals assessed with dual-energy computed tomography or ultrasonography with cardiovascular risk in the commonly high-risk gout patient

Arthritis Research & Therapy
Tristan PascartJean-François Budzik

Abstract

Gout is associated with higher cardiovascular risk that increases with disease severity. The objective of this study was to explore the relationship between the extent of monosodium urate (MSU) crystal deposition, assessed with ultrasonography (US) and dual-energy computed tomography (DECT), and cardiovascular risk. Gout patients were included in this cross-sectional study to undergo DECT scans for the assessment of total MSU volume deposition in the knees and feet, and US to evaluate the number of joints with the double contour (DC) sign. Participants were screened for traditional cardiovascular risk factors, and levels of the American College of Cardiology (ACC)/American Heart Association (AHA) 10-year risk for heart disease or stroke were calculated. The primary endpoint was the Spearman correlation coefficient ρ between DECT MSU volume and cardiovascular risk. A total of 42 patients were included; they were predominantly male (40/42) and aged 63.0 ± 13.2 years. Overall, 28/42 patients presented with the metabolic syndrome and the average 10-year coronary event or stroke risk according to the ACC/AHA (n = 33) was 21 ± 15%. Correlations between DECT volumes of MSU deposits in the knees, feet, and knees + feet and cardiovascul...Continue Reading

References

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Citations

Jul 13, 2019·Zeitschrift für Rheumatologie·J Braun, U Kiltz
Apr 16, 2020·Current Rheumatology Reports·Georgios FilippouAnnamaria Iagnocco
Dec 15, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·André Ramon, Paul Ornetti
Jun 22, 2021·Frontiers in Medicine·Muhammad Israr AhmadSavvas Nicolaou
Jan 17, 2022·Current Opinion in Rheumatology·Tristan Pascart, Jean-François Budzik

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

syngo
R
DECT

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