Abstract
To assess the clinical value of peritoneal washing cytology (PWC) in women with BRCA1 or BRCA2 mutations and women from a family with hereditary breast and/or ovarian cancer (HBOC) undergoing risk-reducing salpingo-oophorectomy (RRSO) in detecting primary peritoneal cancer (PPC) or occult ovarian/fallopian tube cancer. A retrospective study of patients with known BRCA1 or BRCA2 mutation or HBOC who underwent RRSO at the Erasmus Medical Centre, Rotterdam, The Netherlands between January 2000-2014. Patients with an elevated risk of malignancy prior to the procedure were excluded from primary analysis (elevated CA-125, an ovarian mass, abdominal pain or another gynecological malignancy). A review of the literature was conducted. Of the 471 patients who underwent RRSO, a total of 267 cytology samples were available for analysis. Four samples showed malignant cells, all four patients were diagnosed with ovarian and/or fallopian tube cancer at histologic examination. A fifth patient, of whom no cytology sample was obtained during RRSO, developed primary peritoneal cancer 80 months post RRSO. This study failed to show that cytology is of value during RRSO in detecting primary peritoneal cancer, however 36% of patients with concomitant...Continue Reading
References
Jan 1, 1992·Diagnostic Cytopathology·N Sneige, C V Fanning
Jul 17, 1996·Journal of the National Cancer Institute·R E Zuna, A Behrens
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
Apr 29, 1998·American Journal of Human Genetics·D FordM Zelada-Hedman
Nov 25, 1998·Gynecologic Oncology·G H EltabbakhL E Blumenson
Oct 28, 1999·Cancer·S SharifiJ L Fraser
May 25, 2002·The New England Journal of Medicine·Noah D KauffKenneth Offit
Jun 8, 2002·Gynecologic Oncology·Terence J ColganBarry Rosen
Jan 25, 2006·Gynecologic Oncology·Ram EitanDennis S Chi
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K LeunenI Vergote
Feb 8, 2006·Advances in Anatomic Pathology·Yonghee LeeChristopher P Crum
Jul 13, 2006·JAMA : the Journal of the American Medical Association·Amy FinchUNKNOWN Hereditary Ovarian Cancer Clinical Study Group
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J CallahanMichael G Muto
Jun 11, 2008·Journal of Zhejiang University. Science. B·Chao ZhangLi-hui Wei
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Nov 9, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·K HaldarR Crawford
Mar 20, 2012·Gynecologic Oncology·G LandonN Sneige
Feb 9, 2013·Gynecologic Oncology·C B PowellL Chen
Dec 18, 2013·Gynecologic Oncology·James R ConnerColleen Feltmate
Citations
Sep 1, 2016·Diagnostic Cytopathology·Jefree J Schulte, Ricardo R Lastra
Apr 7, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L MinigM G Patrono
Aug 25, 2018·The Cochrane Database of Systematic Reviews·George U ElejeOnyinye O Okonkwo
Nov 27, 2019·Cancer Medicine·Satoru KyoKentaro Nakayama
Feb 7, 2020·Obstetrics and Gynecology·Sabrina PiedimonteWalter H Gotlieb
May 28, 2020·Hormone Molecular Biology and Clinical Investigation·Laura SabianiGilles Houvenaeghel
Mar 21, 2017·International Cancer Conference Journal·Hanako ShimizuAkihiko Sekizawa
Jul 3, 2019·Obstetrics and Gynecology International·Mako UedaHiroaki Shibahara