PMID: 15219154Jun 29, 2004Paper

The lack of recombination drives the fixation of transposable elements on the fourth chromosome of Drosophila melanogaster

Genetical Research
Carolina Bartolomé, Xulio Maside

Abstract

In regions of suppressed recombination, where selection is expected to be less efficient in removing slightly deleterious mutations, transposable element (TE) insertions should be more likely to drift to higher frequencies, and even to reach fixation. In the absence of excision events, once a TE is fixed it cannot be eliminated from the population, and accumulation of elements thus should become an irreversible process. In the long term, this can drive the degeneration of large non-recombining fractions of the genomes. Chromosome 4 of Drosophila melanogaster has very low levels of recombination, if any, and this could be causing its degeneration. Here we report the results of a PCR-based analysis of the population frequencies of TE insertions in a sample from three African natural populations. We investigated 27 insertions from 12 TE families, located in regions of either suppressed or free recombination. Our results suggest that TE insertions tend to be fixed in the non-recombining regions, particularly on the fourth chromosome. We have also found that this involves all types of elements, and that fixed insertions are significantly shorter and more divergent from the canonical sequence than those segregating in the sample (28....Continue Reading

Citations

Jun 7, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Gustavo C S KuhnFabio M Sene
Mar 31, 2005·Trends in Genetics : TIG·Alejandro Sánchez-GraciaBrian Charlesworth
Apr 2, 2010·Proceedings. Biological Sciences·Sarah SchaackMichael Lynch
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yuh Chwen G Lee, Charles H Langley
Oct 31, 2013·Genome Génome / Conseil National De Recherches Canada·Brent SaylorKarl Cottenie
Aug 16, 2008·BMC Evolutionary Biology·María Pilar García GuerreiroAntonio Fontdevila
Dec 18, 2013·Genetics·Justin P BlumenstielCasey M Bergman
Sep 25, 2014·Annual Review of Genetics·Brian Charlesworth, José L Campos
Jun 27, 2009·Gene·Josefa González, Dmitri A Petrov
Jul 22, 2015·Die Naturwissenschaften·Teresa PalomequePedro Lorite
Oct 24, 2008·PLoS Biology·Josefa GonzálezDmitri A Petrov
Nov 12, 2016·Molecular Biology and Evolution·Yuh Chwen G LeeMia T Levine
Jun 3, 2005·Heredity·D CharlesworthG Marais
Sep 16, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sigrid Steinemann, Manfred Steinemann
Sep 3, 2004·Molecular Biology and Evolution·Daniel E NeafseyDaniel L Hartl
Jul 2, 2018·Genes & Genomics·Min-Jin HanHua-Hao Zhang
Feb 28, 2021·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Igor Costa AmorimRita de Cássia de Moura

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