PMID: 2838124Jun 1, 1988Paper

The Lambert-Eaton myasthenic syndrome. A review of 50 cases

Brain : a Journal of Neurology
J H O'NeillJ Newsom-Davis

Abstract

The clinical and electrophysiological features of 50 consecutive patients with the Lambert-Eaton myasthenic syndrome (LEMS) have been analysed. Carcinoma was detected (CD group) in 25, of whom 21 had small cell lung cancer (SCLC). SCLC was evident within 2 yrs of onset of LEMS symptoms in 20/21 cases, and at 3.8 yrs in 1/21. In the cases in whom no carcinoma was detected (NCD group), 14/25 had a history of LEMS greater than 5 yrs. The dominant neurological features were similar in the CD and NCD groups, and consisted of proximal lower limb weakness (100%), depressed tendon reflexes (92%) with posttetanic potentiation (78%), autonomic features, especially dryness of the mouth (74%) and mild/moderate ptosis (54%). The compound evoked muscle action potential amplitude in abductor digiti minimi was below the lower limit of control values in 48/50, and the increment following maximum voluntary contraction above the upper limit of control values in 48/50. Single fibre electromyographic abnormalities were found in 29/29 cases. The analysis indicates that a patient presenting with LEMS has a 62% risk of an underlying SCLC, and that this risk declines sharply after 2 yrs, becoming very low at 4 to 5 yrs. It is argued that in SCLC cases ...Continue Reading

Citations

Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·Y YamajiJ Takahara
Jan 1, 1997·Muscle & Nerve·A H WellerN L Rosenberg
Sep 17, 1999·Muscle & Nerve·D A Greenberg
May 16, 2001·Muscle & Nerve·P W WirtzJ J Verschuuren
Jan 1, 1993·Annals of Neurology·M R RosenfeldH M Furneaux
Dec 1, 1994·Annals of Neurology·A HormigoJ B Posner
Aug 1, 1997·Annals of Neurology·S A WatermanJ Newsom-Davis
Dec 1, 1990·Muscle & Nerve·M J SchwartzmanG S Kosmorsky
Mar 1, 1991·Muscle & Nerve·J V Trontelj, E Stålberg
Jul 1, 1991·Muscle & Nerve·M SquierJ Newsom-Davis
Dec 1, 1991·Muscle & Nerve·V ChaudhryD R Cornblath
Jul 1, 1993·Muscle & Nerve·L GutmannA Gutiérrez
Oct 1, 1996·Muscle & Nerve·W Marques, A A Barreira
Jan 1, 1996·Springer Seminars in Immunopathology·J Dalmau, J B Posner
Oct 19, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S A Waterman
Jan 1, 1996·Pflügers Archiv : European journal of physiology·J Molgó, J M Guglielmi
Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P J Morgan
Jul 18, 2009·Zeitschrift für Rheumatologie·W Marouf, J P Sieb
Apr 19, 2005·Journal of Neurology·F Purroy GarcíaX Montalban
Aug 30, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Steven Vernino
Feb 17, 2001·Current Treatment Options in Neurology·John Newsom-Davis
Feb 13, 2009·Current Treatment Options in Neurology·Maria B Weimer, Joaquin Wong
Jan 12, 2013·Current Treatment Options in Neurology·Jean-Christophe Antoine, Jean-Philippe Camdessanché
Nov 1, 1995·Journal of the Neurological Sciences·M TakamoriT Nakamura
Jun 1, 1996·Journal of the Neurological Sciences·A J McDougall, J G McLeod

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