The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells

Clinical & Experimental Metastasis
Jean A EngbringJennifer E Koblinski

Abstract

Laminin-111 promotes the malignant phenotype, and a 12-mer synthetic peptide (AG73, RKRLQVQLSIRT) from the carboxyl terminus of the alpha1 chain increases B16F10 melanoma metastasis to the lung and liver. Using an antibody array, fibronectin was identified as an up-regulated protein in B16F10 cells after incubation with this peptide. The increased fibronectin is cell-associated with no increase in soluble fibronectin. The AG73 peptide increased the number and size of bone metastases with both B16F10 melanoma and MDA-231 breast carcinoma cells in an intracardiac injection model. Using siRNA transfection, we found that a reduction in fibronectin expression did not reduce bone metastasis in the presence of the metastasis-promoting peptide AG73. We conclude that the laminin peptide AG73 increases metastasis independently of fibronectin expression.

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Citations

Dec 25, 2012·Cell Adhesion & Migration·Yamato KikkawaJennifer E Koblinski
Apr 2, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Letícia N Gama-de-SouzaRuy G Jaeger
Sep 24, 2016·PloS One·Madhavi PuchalapalliJennifer E Koblinski
Jul 22, 2019·Breast Cancer Research and Treatment·Megan R SayyadJennifer E Koblinski
Jun 12, 2019·Analytical Cellular Pathology (Amsterdam)·Madhavi PuchalapalliJennifer E Koblinski
Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Baogang J XuHarold L Moses

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