The Landscape of Adaptive Evolution of a Gut Commensal Bacteria in Aging Mice.

Current Biology : CB
Hugo C BarretoIsabel Gordo

Abstract

Aging is a complex process, with many associated time-dependent phenotypes. The gut microbiota have long been postulated as an important factor in shaping healthy aging [1, 2]. During aging, changes in the microbiota composition occur, with taxa that are rare in adults becoming dominant in the elderly [3, 4]. Increased inflammation associated with aging is also known to modulate and be modulated by the microbiota [5]. Ecological interactions are known to affect the evolution of bacteria both in vitro [6] and in vivo [7], but the extent to which these and the host age-dependent inflammatory environment can alter the pattern of evolutionary change of a gut commensal lineage is still unknown [8]. Here, we provide the first genomic analysis of such evolution in cohorts of old mice, under controlled host genetics and lifestyle conditions. We find that Escherichia coli evolution when colonizing the gut of old mice significantly differs from its evolution in young mice. Evolution toward metabolic adaptation is slower in old than young mice, and mutational targets concerning stress-related functions were found specifically in the inflamed gut of old mice. Taking the genetic basis of E. coli short-term evolution as a reflection of the e...Continue Reading

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Citations

Oct 6, 2020·Communicative & Integrative Biology·Hugo C BarretoIsabel Gordo
Mar 26, 2020·Current Biology : CB·Kayla C KingGeorgia C Drew
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Ci HanChangsong Wang
Apr 11, 2021·Journal of Hazardous Materials·Pengqiang DuYongquan Zheng
Apr 21, 2021·Nature Reviews. Microbiology·Georgia C DrewKayla C King
May 14, 2021·PLoS Pathogens·Emily J StevensKayla C King
Aug 25, 2021·The American Journal of Pathology·Xinwei JiaoZhijie Li

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