The Landscape of Digital Pathology in Transplantation: From the Beginning to the Virtual E-Slide

Journal of Pathology Informatics
Ilaria GirolamiAlbino Eccher

Abstract

Digital pathology has progressed over the last two decades, with many clinical and nonclinical applications. Transplantation pathology is a highly specialized field in which the majority of practicing pathologists do not have sufficient expertise to handle critical needs. In this context, digital pathology has proven to be useful as it allows for timely access to expert second-opinion teleconsultation. The aim of this study was to review the experience of the application of digital pathology to the field of transplantation. Papers on this topic were retrieved using PubMed as a search engine. Inclusion criteria were the presence of transplantation setting and the use of any type of digital image with or without the use of image analysis tools; the search was restricted to English language papers published in the 25 years until December 31, 2018. Literature regarding digital transplant pathology is mostly about the digital interpretation of posttransplant biopsies (75 vs. 19), with 15/75 (20%) articles focusing on agreement/reproducibility. Several papers concentrated on the correlation between biopsy features assessed by digital image analysis (DIA) and clinical outcome (45/75, 60%). Whole-slide imaging (WSI) only appeared in re...Continue Reading

References

Feb 16, 2019·Transplantation·Michelle A Wood-TrageserAnthony J Demetris

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Citations

Jun 11, 2020·Current Opinion in Organ Transplantation·Michelle A Wood-TrageserAnthony J Demetris
Jan 24, 2020·Frontiers in Medicine·Rossana C N MeloThiago P Silva

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Methods Mentioned

BETA
light microscopy
biopsies
biopsy

Software Mentioned

LM
DIA

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