The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome

Molecular Aspects of Medicine
Thomas RiedJordi Camps

Abstract

Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic imbalances, which emerge in premalignant precursor lesions. Moreover, increasing levels of chromosomal instability have been observed in adenocarcinomas and are maintained in distant metastases. A number of studies have systematically integrated copy number alterations with gene expression changes in primary carcinomas, cell lines, and experimental models of aneuploidy. In fact, chromosomal aneuploidies target a number of genes conferring a selective advantage for the metabolism of the cancer cell. Copy number alterations not only have a positive correlation with expression changes of the majority of genes on the altered genomic segment, but also have effects on the transcriptional levels of genes genome-wide. Finally, copy number alterations have been associated with disease outcome; nevertheless, the translational applicability in clinical practice requires further studies. Here, we (i) review the spectrum of genetic alterations that lead to colorectal cancer, (ii) describe the most frequent copy number alterations at different stages of colorec...Continue Reading

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Citations

Oct 18, 2020·Biomedicines·Ugo TestaElvira Pelosi
Feb 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jasni Viralippurath AshrafEyad Elkord
Jul 22, 2021·Molecular Nutrition & Food Research·Hatim BoughanemManuel Macias-Gonzalez
Aug 10, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yueqiang JiangTiejun Yin
Sep 22, 2021·Journal of Molecular Biology·Shalaka PatilKundan Sengupta

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