The Landscape of Intertwined Associations in Homooligomeric Proteins

Biophysical Journal
Shoshana J WodakStephen S MacKinnon

Abstract

We present an overview of the full repertoire of intertwined associations in homooligomeric proteins. This overview summarizes recent findings on the different categories of intertwined associations in known protein structures, their assembly modes, the properties of their interfaces, and their structural plasticity. Furthermore, the current body of knowledge on the so-called three-dimensional domain-swapped systems is reexamined in the context of the wider landscape of intertwined homooligomers, with a particular focus on the mechanistic aspects that underpin intertwined self-association processes in proteins. Insights gained from this integrated overview into the physical and biological roles of intertwining are highlighted.

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Citations

Jun 9, 2016·Biophysical Journal·Jaie C WoodardEugene I Shakhnovich
Nov 22, 2016·Progress in Biophysics and Molecular Biology·Nahren Manuel Mascarenhas, Shachi Gosavi
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anne-Frances MillerAndreas S Bommarius
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco Giampà, Elvira Sgobba
May 15, 2019·Journal of Molecular Biology·Christopher R KimberlinDaniel L Minor
Apr 23, 2021·Journal of Molecular Biology·Andrew M NataleDaniel L Minor

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