The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner

Molecular Cell
V PennaneachA Fotedar

Abstract

Retinoblastoma (Rb) protein promotes cell survival after DNA damage. We show here that the LxCxE binding site in Rb mediates both cell survival and cell-cycle arrest after DNA damage. Replication factor C (RF-C) complex plays an important role in DNA replication. We describe a novel function of the large subunit of RF-C in promoting cell survival after DNA damage. RF-Cp145 contains an LxCxE motif, and mutation of this motif abolishes the protective effect of RF-Cp145. The inability of wild-type RF-Cp145 to promote cell survival in Rb-null cells is rescued by Rb but not by Rb mutants defective in binding LxCxE proteins. RF-C thus enhances cell survival after DNA damage in an Rb-dependent manner.

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Citations

Jul 20, 2006·DNA and Cell Biology·Kazuhiro IshikawaToshiyuki Saito
Jan 14, 2005·Molecular Biology of the Cell·Soheil NaderiHeidi K Blomhoff
Mar 16, 2005·Nucleic Acids Research·Emily E Bosco, Erik S Knudsen
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Jan 20, 2017·BioMed Research International·Chiharu Uchida
Jun 5, 2002·The Journal of Biological Chemistry·Lisa A Anderson, Neil D Perkins

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