The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy

Electroencephalography and Clinical Neurophysiology
A D KrystalC E Coffey

Abstract

Attributes of the electroencephalogram (EEG) recorded during electroconvulsive therapy (ECT) seizures appear promising for decreasing the uncertainty that exists about how to define a therapeutically adequate seizure. In the present report we study whether one promising and not yet tested ictal EEG measure, the largest Lyapunov exponent (lambda1), is useful in this regard. We calculated lambda1 from 2 channel ictal EEG data recorded in 25 depressed subjects who received right unilateral ECT. We studied the relationship of lambda1 to treatment therapeutic outcome and to an indirect measure of treatment therapeutic potency, the extent to which the stimulus intensity exceeds the seizure threshold. We found lambda1 could be reliably calculated from ictal EEG data and that the global mean, maximum, and standard deviation of lambda1 were smaller in the more therapeutically potent moderately suprathreshold ECT and in therapeutic responders. These results imply a more predictable or consistent pattern of EEG seizure activity over time in more therapeutically effective ECT seizures. These findings also suggest the promise of lambda1 as a marker of ECT seizure therapeutic adequacy and build on our previous work suggesting that lambda1 ma...Continue Reading

References

Jan 1, 1986·Annals of the New York Academy of Sciences·R D WeinerL R Squire
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·A D KrystalC E Coffey
Jan 1, 1994·Annual Review of Medicine·R D Weiner, A D Krystal
Nov 4, 1996·Journal of Affective Disorders·T SuppesH G Pope

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Citations

Jan 1, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A D KrystalM West
Dec 24, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Martijn ArnsJan A Freund
Jul 17, 2004·Annual Review of Biomedical Engineering·Nitish V Thakor, Shanbao Tong
Dec 29, 2000·Depression and Anxiety·A D KrystalR D Weiner
Jun 8, 2018·European Archives of Psychiatry and Clinical Neuroscience·Laura KranasterAlexander Sartorius
Jul 17, 1999·The American Journal of Physiology·J GonzálezE Pereda

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