Abstract
The RNA binding motif protein 4 genes RBM4a and RBM4b are located on human chromosome 11q13.2 and encode highly similar proteins of 363 and 359 amino acids, respectively. They contain two RNA recognition motifs (RRMs) and a retroviral-type Zn-finger. RBM4a binds RNA, is involved in alternative splicing and is also a part of the microRNA-processing RISC complex. In particular, RBM4a is involved in exon 10 inclusion of the tau protein. The function of RBM4b is unknown. With new monoclonal antibodies we show that RBM4a is detectable in virtually all tissues and cell lines tested while RBM4b was only found in kidney and liver. Both RBM4a and RBM4b are nuclear phosphoproteins with half-lives of 2.5h and 4.5h, respectively. To our knowledge, this is the first description of RBM4b protein in human tissue. In human brain, expression of RBM4a was strongly up-regulated in cerebellum as compared to forebrain.
References
May 1, 1997·Genomics·F R JacksonE Rossi
Sep 19, 2000·Journal of Neurobiology·X ZhangF R Jackson
Jul 4, 2001·Pathology, Research and Practice·B F RomeikeS M Urbschat
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Sally L DennisElizabeth M Algar
Apr 1, 1995·Virology·E KremmerF A Grässert
Dec 7, 2002·Proteomics·Günter BernertGert Lubec
Mar 12, 2003·The EMBO Journal·Ming-Chih LaiWoan-Yuh Tarn
Sep 29, 2004·Genesis : the Journal of Genetics and Development·Gerard P McNeilRobert Galioto
Dec 24, 2004·Biochimica Et Biophysica Acta·Ian D'Souza, Gerard D Schellenberg
Jun 17, 2006·The Journal of Biological Chemistry·Amar KarJane Y Wu
Aug 15, 2006·Acta Neuropathologica·Heiko BraakKelly Del Tredici
Aug 16, 2006·DNA and Cell Biology·M Andrea Markus, Brian J Morris
Aug 29, 2006·Experimental Cell Research·M Andrea MarkusBrian J Morris
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jung-Chun LinWoan-Yuh Tarn
May 26, 2007·Brain : a Journal of Neurology·David R WilliamsTamas Revesz
Oct 13, 2007·EMBO Reports·Julia HöckGunter Meister
Citations
May 7, 2009·The Journal of Biological Chemistry·Yang S BrooksLan Ko
Jul 21, 2012·International Journal of Cancer. Journal International Du Cancer·Jaroslaw SzczyrbaFriedrich A Grässer
Mar 14, 2013·The FEBS Journal·Martin HartBernd Wullich
Aug 8, 2015·Molecular Biology Reports·Esmaeil EbrahimieJagoda Ignjatovic
May 20, 2011·Molecular Cancer Research : MCR·Jaroslaw SzczyrbaFriedrich A Grässer