The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord

Development
Yanina L PetraccaGuillermo M Lanuza

Abstract

Considerable progress has been made in understanding the mechanisms that control the production of specialized neuronal types. However, how the timing of differentiation contributes to neuronal diversity in the developing spinal cord is still a pending question. In this study, we show that cerebrospinal fluid-contacting neurons (CSF-cNs), an anatomically discrete cell type of the ependymal area, originate from surprisingly late neurogenic events in the ventral spinal cord. CSF-cNs are identified by the expression of the transcription factors Gata2 and Gata3, and the ionic channels Pkd2l1 and Pkd1l2. Contrasting with Gata2/3(+) V2b interneurons, differentiation of CSF-cNs is independent of Foxn4 and takes place during advanced developmental stages previously assumed to be exclusively gliogenic. CSF-cNs are produced from two distinct dorsoventral regions of the mouse spinal cord. Most CSF-cNs derive from progenitors circumscribed to the late-p2 and the oligodendrogenic (pOL) domains, whereas a second subset of CSF-cNs arises from cells bordering the floor plate. The development of these two subgroups of CSF-cNs is differentially controlled by Pax6, they adopt separate locations around the postnatal central canal and they display ...Continue Reading

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Citations

Aug 31, 2016·Current Opinion in Neurobiology·Urs Lucas Böhm, Claire Wyart
May 18, 2017·The Journal of Comparative Neurology·Juana M PasquiniHéctor R Quintá
Apr 1, 2018·The Journal of Comparative Neurology·Gabriela Edwards-FaretJuan Larraín
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Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hernando Martínez VergaraDetlev Arendt
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Nov 10, 2020·Frontiers in Neuroscience·Lixin YangUwe Strähle
Apr 2, 2021·Frontiers in Cellular Neuroscience·Shuo WangQing Li
Aug 8, 2021·International Journal of Molecular Sciences·Dylan Deska-Gauthier, Ying Zhang

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