PMID: 562May 1, 1975

The late effects of selected immunosuppressants on immunocompetence, disease incidence, and mean life-span. II. Cell-mediated immune activity

Mechanisms of Ageing and Development
W J PetersonT Makinodan

Abstract

The late effects of various immunosuppressive insults on cell-mediated immunity in mice were studied in an attempt to assess the role of immune surveillance in the aging process. Results were obtained using susceptibility to allogeneic tumor cell challenge, graft-versus-host reaction (GVHR), blastogenic response to PHA, a thymus derived T cell-specific plant mitogen, and cytolytic activity against allogeneic tumor cells as measures of immunologic activity. In vivo studies late in life show that resistance to allogeneic tumor cells is significantly decreased in thymectomized mice, whereas those treated with cortisone, cyclophosphamide and sublethal X-ray remain unchanged. Spleen cells from only the thymectomized and the sublethally irradiated mice show reduced activity in the GVHR. No difference is seen in the activity of bone marrow cells. Results consistent with these findings were obtained in in vitro studies. Thus spleen cells from thymectomized or sublethally irradiated mice show decreased activity is response to PHA, whereas no change is seen in spleen cells from other treated groups. Hence, surgical and physical insults are more likely to induce long-lasting immunosuppression in those immunocompetent tissues whose activit...Continue Reading

References

Oct 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·Y HoriM K Halsall
Jan 1, 1972·Gerontologia·L J Greenberg, E J Yunis
Jan 1, 1971·Transplantation Reviews·F M Burnet
Jul 1, 1968·Annals of Internal Medicine·R M FreemanM O Fearing
Sep 1, 1993·Critical Care Medicine·A E Thompson
Jul 1, 1957·Journal of Gerontology·A C UPTON
Jul 1, 1960·British Journal of Haematology·D METCALF
Oct 2, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kenneth J McPartland, James J Pomposelli

Related Concepts

Age Factors
Metazoa
Adreson
Cyclophosphamide, (S)-Isomer
Microcytotoxicity Test
Graft Vs Host Reaction
Cellular Immune Response
Therapeutic Immunosuppression
Longevity
Lymphocyte Activation

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