PMID: 11911711Mar 26, 2002Paper

The "latent membrane permeability" concept: QSPR analysis of inter/intralaboratory variable Caco-2 permeability

Journal of Chemical Information and Computer Sciences
Fumiyoshi YamashitaMitsuru Hashida

Abstract

Caco-2 cell monolayers grown on a filter support are the most widely used systems for predicting intestinal absorption. However, inter- and intralaboratory variability in Caco-2 permeability makes it difficult to analyze any QSPR relationship for a large number of compounds. We proposed the "latent membrane permeability" concept, assuming that all Caco-2 permeability data sets share a hidden, common relationship between their membrane permeability and physicochemical properties. An iterative calculation method was developed to handle this conceptual approach and applied to the analysis of Caco-2 permeability data sets from different sources. A thorough statistical analysis revealed that the "latent membrane permeability" concept be reasonable.

References

Mar 1, 1988·British Journal of Clinical Pharmacology·R A PrentisS R Walker
Jan 1, 1996·Journal of Pharmaceutical Sciences·K PalmP Artursson
Apr 20, 2001·Journal of Medicinal Chemistry·H van De WaterbeemdD K Walker

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Citations

Apr 6, 2006·The AAPS Journal·Stephen R Johnson, Weifan Zheng
Sep 23, 2003·Journal of Pharmaceutical Sciences·Shin-Ichi FujiwaraMitsuru Hashida
May 5, 2004·Journal of Pharmaceutical Sciences·Kazuto Yamazaki, Masaharu Kanaoka
Mar 29, 2016·Journal of Chemical Information and Modeling·Ning-Ning WangDong-Sheng Cao
Apr 18, 2011·Molecular Informatics·Hai Pham TheMiguel Ángel Cabrera-Pérez
Nov 19, 2004·Drug Metabolism and Pharmacokinetics·Fumiyoshi Yamashita, Mitsuru Hashida
Dec 1, 2018·Current Topics in Medicinal Chemistry·Hai Pham-TheGerardo M Casañola-Martin
Jul 14, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Paulo PaixãoJosé A G Morais

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