The lateral compartmentation of the yeast plasma membrane

Yeast
Jan MalinskyWidmar Tanner

Abstract

The plasma membrane of Saccharomyces cerevisiae contains large microdomains enriched in ergosterol, which house at least nine integral proteins, including proton symporters. The domains adopt a characteristic structure of furrow-like invaginations typically seen in freeze-fracture pictures of fungal cells. Being stable for the time comparable with the cell cycle duration, they might be considered as fixed islands (rafts) in an otherwise fluid yeast plasma membrane. Rapidly moving endocytic marker proteins avoid the microdomains; the domain-accumulated proton symporters consequently show a reduced rate of substrate-induced endocytosis and turnover.

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Citations

May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fatih DemirInes Kreuzer
Oct 19, 2012·Journal of Cell Science·Jürgen J HeinischYves F Dufrêne
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