PMID: 9556753Jun 1, 1997Paper

The latest seroepidemiological pattern of hepatitis A in Japan

Japanese Journal of Medical Science & Biology
T KiyoharaY Moritsugu

Abstract

Age-specific prevalence of anti-hepatitis A virus antibody (anti-HAV) was surveyed with 2,708 sera collected in 1994 in various areas of Japan. By age-group analyses, we found strong association of anti-HAV antibody with higher age group. The prevalence ratios of antibody in the groups of 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64 and 65 years or older were 0, 4.2, 22.0, 44.8, 57.6, 76.4, 84.5 and 91.4%, respectively. Geometric mean titers of anti-HAV antibody in the positive age groups were approximately 6,000 mIU/ml. The seropositives among older population were ascribed to the infections more than 40 years ago and the high anti-HAV titers have been maintained since that time. In Japan, people younger than 40 years of age are extremely risky to HAV infection, since 99% have no antibody. Those in forties are also risky since two-thirds of them are seronegative. In Japan, an inactivated vaccine was licensed in 1994. Vaccination may be recommended for such high-risk groups as travelers going to endemic areas, patients who have received blood product medication and child-care staffs.

References

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Citations

Mar 13, 2001·The Journal of Infection·K HayashiJ Takamatsu
Feb 21, 2007·Microbiology and Immunology·Tomoko KiyoharaTetsuo Yoneyama
Jul 11, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Atsuko TominagaNobuyuki Sugiura
Jan 27, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hidenori ToyodaHsin-Fu Liu
Mar 1, 2012·Osong Public Health and Research Perspectives·Haesun YunMi Kyung Kim
Nov 11, 2006·Journal of Gastroenterology·Hideaki TakahashiFumio Itoh
Aug 13, 1999·The American Journal of Gastroenterology·T FujisawaY Matsunaga
Apr 16, 2005·International Journal of Epidemiology·K H Jacobsen, J S Koopman
Feb 8, 2019·Scientific Reports·Chikako YamamotoJunko Tanaka
Feb 15, 2005·Journal of Virology·Dino A FeigelstockGerardo G Kaplan

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