PMID: 11934501Apr 6, 2002Paper

The LcnC homologue cannot replace LctT in lacticin 481 export

FEMS Microbiology Letters
Marilyne Uguen, P Uguen

Abstract

Lacticin 481 is produced by Lactococcus lactis subsp. lactis and belongs to subgroup AII of the lanthionine-containing bacteriocins. The putative homodimeric LctT involved in lacticin 481 production shares significant similarities with the 'LcnC' protein encoded by 'lcnC', located on the chromosome of the lactic acid bacterium, L. lactis IL1403. LctT and 'LcnC' belong to the recently defined family of AMS (ABC transporter maturation and secretion) proteins. Inactivation of the 'lcnC' gene demonstrates that it is not responsible for the weak lacticin 481 production observed in a strain expressing only the precursor peptide LctA, and the modification enzyme LctM. This result indicates that the two AMS proteins, 'LcnC' and LctT, are not interchangeable in the machinery of processing/export of lacticin 481.

References

Oct 1, 1996·Antonie van Leeuwenhoek·M E Stiles
Mar 21, 1998·Applied and Environmental Microbiology·N HornH M Dodd
Nov 13, 1998·FEMS Microbiology Letters·L AxelssonA Holck
May 12, 2001·FEMS Microbiology Reviews·O McAuliffeC Hill

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Citations

Jan 11, 2005·Applied and Environmental Microbiology·Patricia UguenAlain Dufour
Jun 24, 2008·Biochemistry·L A Furgerson IhnkenWilfred A van der Donk
Mar 22, 2018·Applied Microbiology and Biotechnology·Sen Zheng, Kenji Sonomoto
Feb 11, 2005·Chemical Reviews·Champak ChatterjeeWilfred A van der Donk

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