The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents

Journal of Ethnopharmacology
Enitome E BaforRuAngelie Edrada-Ebel

Abstract

In the search for new, safe and efficacious uterine active agents, the plant Ficus exasperata was subjected to phytochemical screening and pharmacological analysis. Ethyl acetate and methanolic leaf extracts of Ficus exasperata were fractionated and purified by a series of chromatographic techniques. The isolation process was guided by in vitro functional uterine assays involving the use of C57Bl/6 female mice. Identification of the active chemical constituents was performed by several spectroscopic techniques which included 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS). The uterine effects of these compounds were investigated on spontaneous, oxytocin-induced and high KCl-induced contractions using isolated uterine segments of non-pregnant female mice. The activity of different compounds on the amplitude (maximum tension above basal force) and frequency of uterine contractions were simultaneously measured and then statistically analysed. The structure-activity relationships were also examined where possible. These studies led to the identification of some new phytochemical derivatives. Pharmacological assay revealed the presence of both uterine stimulatory and inhibitory constituents. T...Continue Reading

References

Feb 28, 2002·Biophysical Journal·Eun Hui LeeDo Han Kim
Aug 13, 2002·Analytical and Bioanalytical Chemistry·Andreas Prange, Dirk Schaumlöffel
Feb 11, 2003·Chemical & Pharmaceutical Bulletin·Muntha Kesava ReddyBernard Bodo
May 1, 2007·Journal of Ethnopharmacology·Clara CircostaFrancesco Occhiuto
Nov 26, 2010·Seminars in Perinatology·Joy E LawnSimon Cousens
Mar 16, 2011·Chemistry & Biodiversity·Fadzly Adzhar KamarulzamanHong Boon Lee
Apr 5, 2011·American Journal of Obstetrics and Gynecology·George A MaconesAnthony Odibo
May 24, 2011·American Journal of Obstetrics and Gynecology·Denis J Crankshaw, John J Morrison
Aug 2, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R WächterU von Mandach
Jan 20, 2012·Acta Crystallographica. Section E, Structure Reports Online·Qi YangPing-Fang Han

Related Concepts

Mice, Inbred C57BL
Syntocinon
Plant Extracts
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Uterine Contraction
Uterus
Tocolytic Effect
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