The Leeuwenhoek Lecture, 1997. Marek's disease herpesvirus: oncogenesis and prevention

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
P M Biggs

Abstract

There are a number of neoplasias for which a herpesvirus is an essential part of the aetiology. Of these, Marek's disease is the most common and provides excellent opportunities for the study of a herpesvirus-induced tumour both experimentally and under natural conditions in the field. Marek's disease is caused by an alpha herpesvirus; it differs from the other oncogenic herpesviruses which are gamma herpesviruses. It is a ubiquitous virus in poultry populations of the world and is highly cell-associated and contagious, yet only a proportion of infected fowl develop tumours. Evidence is presented to suggest that at least one of the reasons for a wide variation in the incidence of the disease is a temporal interplay between virulent viruses and viruses of low or no virulence. The viral genes associated with the oncogenicity of Marek's disease virus (MDV) are discussed and it is concluded that it is likely that several genes are involved. Finally, a brief history of vaccination to control Marek's disease is given and mode of action discussed. It is concluded that the mechanism of protection is mainly through an antiviral cell mediated immune response, resulting in a lowered challenge virus burden. Marek's disease viruses over the...Continue Reading

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Citations

Jul 31, 2002·Molecular Pathology : MP·E Le RouzicB Perbal
Mar 4, 2014·Veterinary Research Communications·Xuming HuJianqiang Ye
Jul 17, 2009·The Journal of General Virology·P G StevensonS Efstathiou
Jun 6, 2009·The Journal of Veterinary Medical Science·Rika KanoKazuhiko Ohashi
Aug 4, 2009·Veterinary Immunology and Immunopathology·Hikmet KelesYilmaz Dundar
Jul 28, 2009·Analytical and Bioanalytical Chemistry·A Renee SilerRobert A Walker
Apr 2, 2010·Journal of Fluorescence·Alexander P Demchenko
Feb 21, 2006·Archives of Virology·M NiikuraH H Cheng
Mar 17, 2020·The Journal of Poultry Science·Yang Wang
Jan 26, 2018·Journal of Veterinary Science·Dan WangMohammad Heidari

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