The LEGACY Girls Study: Growth and Development in the Context of Breast Cancer Family History

Epidemiology
Esther M JohnIrene L Andrulis

Abstract

Although the timing of pubertal milestones has been associated with breast cancer risk, few studies of girls' development include girls at increased breast cancer risk due to their family history. The Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study was initiated in 2011 in the USA and Canada to assess the relation between early life exposures and intermediate markers of breast cancer risk (e.g., pubertal development, breast tissue characteristics) and to investigate psychosocial well being and health behaviors in the context of family history. We describe the methods used to establish and follow a cohort of 1,040 girls ages 6-13 years at baseline, half with a breast cancer family history, and the collection of questionnaire data (family history, early life exposures, growth and development, psychosocial and behavioral), anthropometry, biospecimens, and breast tissue characteristics using optical spectroscopy. During this initial 5-year phase of the study, follow-up visits are conducted every 6 months for repeated data and biospecimen collection. Participation in baseline components was high (98% for urine, 97.5% for blood or saliva, and 98% for anthropometry). At enrollment, 77% of girls wer...Continue Reading

References

Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Mar 6, 2003·Psycho-oncology·Casey A Harris, Sandra G Zakowski
Sep 24, 2004·British Journal of Cancer·A C AntoniouD F Easton
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Valerie A McCormack, Isabel dos Santos Silva
Jan 22, 2008·Breast Cancer Research : BCR·Sue Kyung ParkLouise A Brinton
Jun 26, 2009·Patient Education and Counseling·Randi Shedlosky-ShoemakerKimberly M Kelly
Apr 26, 2011·Social Science & Medicine·Jason D Boardman, Kari B Alexander
Apr 25, 2012·Cancer Causes & Control : CCC·Somdat MahabirRebecca Troisi
Oct 16, 2012·Breast Cancer Research and Treatment·Angela R BradburyMary B Daly
Jan 10, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Somdat Mahabir
Nov 1, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Lissette Delgado-CruzataMary Beth Terry
Feb 6, 2014·Breast Cancer Research : BCR·Danielle H BodicoatAnthony J Swerdlow
Apr 24, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Hui-Chen WuMary Beth Terry
May 23, 2014·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Diana HarrisAngela R Bradbury

❮ Previous
Next ❯

Citations

Feb 9, 2017·Breast Cancer Research : BCR·Lothar LilgeIrene L Andrulis
Feb 14, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Hui-Chen WuMary Beth Terry
Sep 28, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Heather C M AllawayMary Jane De Souza
Jun 29, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Andreas ErnstCecilia H Ramlau-Hansen
Jun 10, 2017·Breast Cancer Research : BCR·Mary Beth TerryEsther M John
Jan 11, 2017·BMC Cancer·Parisa TehranifarMary Beth Terry
Oct 16, 2020·American Journal of Epidemiology·Julia A KnightMary Beth Terry
Mar 19, 2021·Preventing Chronic Disease·Christopher D PfleddererCaren J Frost
Nov 1, 2020·American Journal of Epidemiology·Jasmine A McDonaldMary Beth Terry
Jul 14, 2021·Circulation. Genomic and Precision Medicine·Priyanka AhimazWendy K Chung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.