The Legionella pneumophila hel locus encodes intracellularly induced homologs of heavy-metal ion transporters of Alcaligenes spp.

Infection and Immunity
M S McClainN C Engleberg

Abstract

We continued characterization of the Legionella pneumophila hel locus. Mutagenesis and DNA sequencing identified three genes similar to the czc and cnr loci of Alcaligenes eutrophus and the ncc locus of Alcaligenes xylosoxidans. On the basis of their similarity to these loci, we designated the L. pneumophila genes helC, helB, and helA. Mutations in the hel genes led to reduced cytopathicity towards U937 cells, although the mutant strains did not appear defective in other assays of virulence. Transcription of the hel locus was induced by the intracellular environment but was not induced by any of a variety of in vitro stress conditions. The function of the hel gene products remains to be determined.

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Citations

Jan 1, 1996·Annual Review of Microbiology·S Silver, L T Phung
Jun 26, 2012·Applied and Environmental Microbiology·Vicente Gomez-AlvarezJorge W Santo Domingo
Feb 22, 2017·Frontiers in Microbiology·Ramon Hochstrasser, Hubert Hilbi
Sep 24, 1999·Electrophoresis·Y A Kwaik, O S Harb
Aug 14, 1999·Molecular Microbiology·B K Hammer, M S Swanson
Jun 1, 2011·Environmental Microbiology Reports·Hubert HilbiChristopher F Harrison
Jul 23, 1999·Infection and Immunity·A D Joshi, M S Swanson
Jun 28, 2003·FEMS Microbiology Reviews·Dayle K Blencowe, Andrew P Morby
Jun 25, 1998·Infection and Immunity·B Byrne, M S Swanson

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