The LEI/L-DNase II pathway is activated in light-induced retinal degeneration in rats

Neuroscience Letters
Sabine ChahoryA Torriglia

Abstract

Retinal death induced by light seems to be a caspase-independent process. In this work we investigate the LEI/L-DNase II pathway, a caspase-independent pathway, in light-induced retinal degeneration in Fischer rats. Measurement of DNase activity in total retinal extracts of light exposed Fischer rats was performed by analysing a plasmid degradation on an agarose gel. The same method was used to measure the in vitro activity of recombinant LEI (reticulocyte lysate) after incubation with calpains. L-DNase II activity is observed in retinal extracts of light exposed Fischer rats and increases with time illumination. In this apoptotic death, the activation of calpains has been shown. Here we show that L-DNase II activation is not catalized by calpains. The present study indicates that the LEI/L-DNase II may be a possible pathway activated during photoreceptor apoptosis in light-induced retinal degeneration but that this pathway is not directly activated by calpains.

References

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Citations

Mar 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·J FombonneA Torriglia
May 16, 2013·Apoptosis : an International Journal on Programmed Cell Death·Chloé LeprêtreAlicia Torriglia
Apr 19, 2008·DNA and Cell Biology·Ma-feng LiuMing-yuan Liu
Mar 26, 2014·Journal of Molecular Neuroscience : MN·Qinmeng ShuGezhi Xu
Sep 2, 2008·Biochemical Pharmacology·Alicia TorrigliaElisabeth Martin
Sep 23, 2006·Biochimie·Marie-France Counis, Alicia Torriglia
Mar 18, 2015·Journal of Cellular and Molecular Medicine·Imene JaadaneAlicia Torriglia
Apr 12, 2015·Free Radical Biology & Medicine·Imene JaadaneAlicia Torriglia
Apr 8, 2015·DNA and Cell Biology·Dmitry D ZhdanovAlexei G Basnakian
Jun 12, 2013·Biochimica Et Biophysica Acta·Gloria E Villalpando Rodriguez, Alicia Torriglia
Mar 18, 2008·Biochimica Et Biophysica Acta·Chloé LeprêtreAlicia Torriglia
Jul 1, 2017·Journal of Cellular and Molecular Medicine·Imene JaadaneAlicia Torriglia
May 12, 2006·Journal of Cellular Physiology·Laurence HucDominique Lagadic-Gossmann
Aug 17, 2005·Nature Reviews. Molecular Cell Biology·Kumiko Samejima, William C Earnshaw

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