The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease.

The Journal of Biological Chemistry
Eduardo M CastanoB Frangione

Abstract

In hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D), a genetic variant (E22Q) of amyloid beta (Abeta) accumulates predominantly in the small vessels of leptomeninges and cerebral cortex, leading to fatal strokes in the fifth or sixth decade of life. Abeta deposition in the neuropil occurs mainly in the form of preamyloid, Congo red negative deposits, while mature neuritic plaques and neurofibrillary tangles, hallmark lesions in Alzheimer's disease (AD), are characteristically absent. A recent hypothesis regarding the pathogenesis of AD states that Abeta extending to residues 42-43 (as opposed to shorter species) can seed amyloid formation and trigger the development of neuritic plaques followed by neuronal damage in AD. We characterized biochemically and immunohistochemically Abeta from three cases of HCHWA-D to determine its length in vascular and parenchymal deposits. Mass spectrometry of formic acid-soluble amyloid, purified by size-exclusion gel chromatography, showed that Abeta 1-40 and its carboxyl-terminal truncated derivatives were the predominant forms in leptomeningeal and cortical vessels. Abeta 1-42 was a minor component in these amyloid extracts. Immunohistochemistry with antibodies S40 and S42...Continue Reading

References

Apr 30, 1992·Biochemical and Biophysical Research Communications·R OrlandoM G Zagorski
Nov 1, 1991·Annals of Neurology·I Fernandez-MadridB Frangione
Jun 1, 1990·Journal of Neurochemistry·W E Klunk, J W Pettegrew
Jul 1, 1988·Journal of the Neurological Sciences·W LuyendijkB Frangione
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S G van DuinenB Frangione
Dec 15, 1986·Biochemical and Biophysical Research Communications·E M CastañoB Frangione
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Dec 1, 1994·Scandinavian Journal of Immunology·S YakarM Pras
Jun 26, 1995·Biochemical and Biophysical Research Communications·Y HarigayaH Mori
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·G A TennentM B Pepys
Mar 1, 1994·Neurobiology of Aging·T WisniewskiB Frangione
Nov 1, 1993·Journal of Neurochemistry·C Vigo-PelfreyD B Schenk
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A E RoherM J Ball
Feb 15, 1993·Archives of Biochemistry and Biophysics·D L MillerK Iqbal
Jan 15, 1996·The Biochemical Journal·T WisniewskiB Frangione
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Davis, W E Van Nostrand
Jan 1, 1996·Journal of the American Society for Mass Spectrometry·R C Beavis

❮ Previous
Next ❯

Citations

Nov 10, 2009·Cellular and Molecular Life Sciences : CMLS·A RostagnoJorge Ghiso
Feb 4, 2009·Cellular and Molecular Life Sciences : CMLS·R J S VianaC M P Rodrigues
Oct 24, 2003·Brain Research. Brain Research Reviews·Annemieke A M RensinkMarcel M Verbeek
Jan 27, 2004·Journal of Molecular Biology·Anna SandersRosemary A Staniforth
Jun 11, 2002·Journal of Molecular Biology·Christopher M YipJoAnne McLaurin
Jan 6, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T HarkanyC Nyakas
Aug 28, 2004·Nature Neuroscience·Jorge Ghiso, Thomas Wisniewski
Dec 31, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Marion Maat-SchiemanSjoerd van Duinen
Apr 15, 2006·Brain Pathology·Martin C HerzigMathias Jucker
Jul 25, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Fuyuki Kametani, Shu-ichi Ikeda
Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·M L SelenicaA Grubb
Feb 20, 2007·Neurobiology of Aging·Mireia ComaFrancisco J Muñoz
Oct 12, 2016·Acta Neuropathologica Communications·Sonia MazzitelliMichela Matteoli
Oct 20, 2010·Annals of the New York Academy of Sciences·Vitaly VasilevkoDavid H Cribbs
Jul 31, 2019·Annals of Neurology·Aaron P SchultzSteven M Greenberg
Jun 25, 2003·The Journal of Biological Chemistry·Vishwanath KoppakaPaul H Axelsen
Jul 31, 2002·Brain Pathology·Tamas ReveszBlas Frangione
Jan 13, 2011·Neurologia i neurochirurgia polska·Tadeusz Mendel, Grażyna Gromadzka
Apr 15, 2006·Brain Pathology·Sandy X Zhang-NunesSteven M Greenberg
Oct 1, 2017·Clinical Science·Lieke JäkelMarcel M Verbeek
May 8, 2020·The Journal of Biological Chemistry·Elliot J CrooksLisa M Miller
Jan 31, 2021·International Journal of Molecular Sciences·Ziao FuSteven O Smith
Feb 1, 2021·The Journal of Biological Chemistry·Elliot J CrooksLisa M Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.