The lesions of cyclosporine-induced autoimmune disease can be equally well elicited by CD4 or CD8 effector T cells

Transplantation
L J BeijleveldP J van Breda Vriesman

Abstract

Lethally irradiated Lewis rats reconstituted with syngeneic bone marrow and given cyclosporine for 4 weeks develop a graft-versus-host-like disease upon withdrawal of CsA. Autoreactive T cells inducing this thymus-dependent autoimmune disease, termed CsA-AI, are demonstrable by adoptive transfer, provided regulatory cells in recipient rats are eliminated. Earlier studies have not unequivocally defined the effector T cells responsible for development of CsA-AI. Some of these studies suggest that both CD4 and CD8 T cells are required, while other studies indicate disease transfer by CD4 or CD8 T cells only. To further clarify this issue, it was necessary to study putative effector T cells in a well-defined setting. Hence, adoptive transfer studies were designed wherein the effect of the T cells of interest could be studied without being influenced by T cells of unwanted origin. Accordingly, recipient rats were thymectomized prior to irradiation, lymph node cells (LNC) from diseased donor rats were depleted of CD4 or CD8 cells before adoptive transfer, and recipients were treated in vivo with CD4- or CD8-depleting mAb. The results showed that CsA-AI developed after adoptive transfer with LNC depleted of either CD4 or CD8 cells. An...Continue Reading

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Citations

Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Magdalena SalcedoGerardo Clemente
Mar 1, 2002·Journal of Autoimmunity·Maurits M BarendrechtJan G M C Damoiseaux
Sep 16, 1998·Clinical and Experimental Immunology·J G DamoiseauxP J van Breda Vriesman
Feb 20, 2003·International Journal of Immunopathology and Pharmacology·J. G.m.c. Damoiseaux

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