PMID: 9159916May 1, 1997Paper

The lessons of Bhopal [toxic] MIC gas disaster scope for expanding global biomonitoring and environmental specimen banking

Chemosphere
S Sriramachari, H Chandra

Abstract

Bhopal Toxic gas tragedy represents one of the worst chemical accidents of the world. Autopsy and toxicological studies, apart from presenting evidence of acute and even chronic cyanide toxicity, provided a unique example of the incriminated chemical being traced to the bodies of the victims. The entry of methyl isocyanate (MIC) into the blood stream was established by the presence of carbamoylated end-terminal amino acids of haemoglobin and other tissue proteins. The presence of MIC trimer and a few other identified as well as unidentified tank residue constituents in the blood and viscera further established a close nexus of the products of pyrolysis of MIC in the aerosol inhaled by the victims. The Bhopal studies exemplify the scope for biological monitoring (BM) and environmental specimen banking (ESB) in chemical accidents as part of the global efforts.

References

Apr 29, 1988·Journal of Chromatography·P K RamachandranS Sriramachari
May 1, 1987·Bulletin of Environmental Contamination and Toxicology·S C PantR Vijayaraghavan
Dec 1, 1985·British Journal of Industrial Medicine·B NemeryD E Ray
Sep 1, 1983·Journal of Analytical Toxicology·F McAuley, D S Reive

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Citations

Oct 1, 2002·Environmental Toxicology and Pharmacology·Farhat N JafferyP N Viswanathan
Feb 6, 2008·International Journal of Phytoremediation·Xiao-Zhang YuLiang Chen
Mar 6, 2007·Journal of Hazardous Materials·Xiao-Zhang YuShuo Liu
Apr 7, 2011·International Journal of Occupational Medicine and Environmental Health·Pradyumna K MishraAruna Jain
Jan 7, 2015·Environmental Technology·Halis SimsekAchintya N Bezbaruah
Jan 21, 2010·Chemical Research in Toxicology·Ronnie DaviesMargareta Törnqvist

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