The lessons of GIST--PET and PET/CT: a new paradigm for imaging

The Oncologist
Annick D Van den Abbeele

Abstract

Traditional anatomic tumor response criteria are based on uni- or bidimensional changes in tumor size, and do not take into account changes in tumor metabolism, tumor density, or decrease in the number of intratumoral vessels. These changes are, however, all indicative of response to imatinib therapy in patients with gastrointestinal stromal tumor (GIST). In these patients, metabolic responses seen on positron emission tomography (PET) using fluorine-18-fluorodeoxyglucose (18FDG) have been shown to be closely related to clinical benefit. Furthermore, these metabolic changes precede by weeks or months significant decrease in tumor size on computed tomography (CT). Conversely, lack of metabolic response on FDG-PET indicates primary resistance to the drug and may help identify patients who would benefit from another therapy, while re-emergence of metabolic activity within tumor sites following a period of therapeutic response indicates secondary resistance to the drug. Newly proposed CT criteria using either no growth in tumor size or a combination of tumor density and size criteria have shown a close correlation with the predictive value results of FDG-PET. Thus, the integration of FDG-PET and CT, as in the combined hybrid PET/CT...Continue Reading

References

Jan 1, 1981·Cancer·A B MillerA Winkler
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Jun 17, 2008·The Oncologist·Haesun Choi

❮ Previous
Next ❯

Citations

Sep 30, 2009·Der Radiologe·G AntochA K Buck
Jul 1, 2011·Archives of Toxicology·Eirini Thanopoulou, Ian Judson
Mar 20, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Sandip Basu
Aug 22, 2009·Wiener medizinische Wochenschrift·Ferdinand PlonerUNKNOWN für das österreichische GIST-Panel
Aug 22, 2009·Wiener medizinische Wochenschrift·Wolfgang Schima, Amir Kurtaran
Aug 15, 2012·Wiener medizinische Wochenschrift·Philipp MalleHans-Jürgen Gallowitsch
Mar 20, 2013·Wiener medizinische Wochenschrift·Evelyne BareckUNKNOWN Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Lab
Jan 30, 2010·Cancer Metastasis Reviews·Georgios S Papaetis, Kostas N Syrigos
Jun 30, 2012·Current Treatment Options in Oncology·Paolo G CasaliAlessandro Gronchi
Jan 14, 2010·Annals of Nuclear Medicine·Ioannis Trigonis, Alan Jackson
Jan 14, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel H StermanSteven M Albelda
Sep 30, 2009·Nature Reviews. Clinical Oncology·Wim J G Oyen, Winette T A van der Graaf
Aug 3, 2011·Nature Reviews. Clinical Oncology·Ignacio Garrido-LagunaRazelle Kurzrock
Apr 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BachnerM De Santis
Aug 18, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A DicksonG K Schwartz
Aug 24, 2012·Current Opinion in Oncology·Camilo GarciaPatrick Flamen
Dec 19, 2009·Pancreas·Yong-Song GuanQing He
Feb 23, 2010·Clinical Nuclear Medicine·Carolyn L WangRex C Bentley
Jun 16, 2010·Clinical Nuclear Medicine·Hayato KaidaNaofumi Hayabuchi
Aug 16, 2013·Ultrasound Quarterly·Nadia Juliet Khati, Susan L Voci
Jun 28, 2011·AJR. American Journal of Roentgenology·Vahid YaghmaiRiad Salem
Sep 26, 2013·AJR. American Journal of Roentgenology·Sree Harsha TirumaniNikhil H Ramaiya
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
May 21, 2014·Current Opinion in Oncology·James A DeCaprio, Anette Duensing
Feb 11, 2014·Abdominal Imaging·Abbey J WinantDouglas A Brylka
Jul 30, 2014·Current Treatment Options in Oncology·Tong DaiManish A Shah
Aug 25, 2012·The British Journal of Radiology·C G CroninS McDermott
Mar 2, 2013·Molecular & Cellular Proteomics : MCP·Nilofer AzadElise C Kohn
Jan 5, 2010·Wiener klinische Wochenschrift·Ferdinand PlonerThomas Brodowicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.