PMID: 9539760May 16, 1998Paper

The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene

Proceedings of the National Academy of Sciences of the United States of America
D M ChambersCatherine M Abbott

Abstract

We have identified the mutation responsible for the autosomal recessive wasted (wst) mutation of the mouse. Wasted mice are characterized by wasting and neurological and immunological abnormalities starting at 21 days after birth; they die by 28 days. A deletion of 15.8 kb in wasted mice abolishes expression of a gene called Eef1a2, encoding a protein that is 92% identical at the amino acid level to the translation elongation factor EF1alpha (locus Eef1a). We have found no evidence for the involvement of another gene in this deletion. Expression of Eef1a2 is reciprocal with that of Eef1a. Expression of Eef1a2 takes over from Eef1a in heart and muscle at precisely the time at which the wasted phenotype becomes manifest. These data suggest that there are tissue-specific forms of the translation elongation apparatus essential for postnatal survival in the mouse.

References

Jul 5, 1992·Journal of Molecular Biology·R GuigóT Smith
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E C Uberbacher, R J Mural
Jan 1, 1991·Annual Review of Biochemistry·J W Hershey
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Sep 1, 1989·Journal of Neuropathology and Experimental Neurology·H L Lutsep, M Rodriguez
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J C ShepherdW J Gehring
Jul 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Chinkers
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L D SiracusaJ Peters

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Citations

Jul 12, 2002·Journal of Cellular Biochemistry·Louis-Bruno RuestEugenia Wang
Aug 10, 2006·Breast Cancer Research and Treatment·Geeta KulkarniJonathan M Lee
Jan 20, 2004·Trends in Biochemical Sciences·Catherine M Abbott, Christopher G Proud
Oct 5, 2001·Trends in Genetics : TIG·H J Newbery, C M Abbott
Sep 6, 2002·Insect Biochemistry and Molecular Biology·Melinda Sue SchwientekAnn Marie Fallon
Jan 30, 2002·Trends in Molecular Medicine·Helen J Newbery, Catherine M Abbott
Aug 8, 2007·Nature Reviews. Genetics·Gert C ScheperChristopher G Proud
Nov 1, 2003·Reproductive Biology and Endocrinology : RB&E·Jonathan M Lee
Aug 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ashwini K MishraDavid G Lambright
Mar 30, 2007·Radiation Research·Jennifer Malone, Robert Ullrich
Jan 20, 2007·Developmental Biology·Liquan CaiDonald D Brown
Jun 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tetsuya S Tanaka, Minoru S H Ko
Apr 6, 2017·Scientific Reports·Faith C J DaviesCatherine M Abbott
Jun 30, 2004·Molecular Carcinogenesis·Pius JosephTong-Man Ong
May 31, 2016·Journal of Cachexia, Sarcopenia and Muscle·Roland W J HangelbroekMichael Müller
May 14, 2003·Circulation·Bogac KaynakSilke Sperling
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Dongsheng LiDavid Harrich
Oct 30, 2018·Human Mutation·Fiona McLachlanCatherine M Abbott
Jun 8, 2002·Nature Genetics·Nisha AnandJonathan M Lee
May 16, 2007·Muscle & Nerve·Mikael AltunBrun Ulfhake
Oct 16, 2007·Neuro-degenerative Diseases·Lindsey R Fischer, Jonathan D Glass
Jun 20, 2008·Evolution; International Journal of Organic Evolution·Roman YukilevichJohn R True
Jul 21, 2007·The Journal of Biological Chemistry·H J NewberyC M Abbott
Aug 31, 2019·EMBO Molecular Medicine·Andrea GrundJoerg Heineke

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