Aug 1, 1989

The Leu 7+ cell population of the human pancreas: preferential distribution and morphology

Bollettino della Società italiana di biologia sperimentale
A LepriniA Nocera


Anti-Leu 7 is a monoclonal antibody which recognizes an antigenic determinant present on the surface of a subset of human large granular lymphocytes and on central and peripheral neural elements. Furthermore it cross-reacts with an intracellular protein of secretory granule matrix in neuroendocrine cells. The presence of Leu 7+ cells has been studied in lymphoid and non-hemopoietic organs. We have analyzed the Leu 7 positivity in six pancreata from cadaver donors by means of immunocytochemical methods. Leu 7+ cells were found to be also present in the exocrine portion of the organ in which they represent a nonhomogeneous cellular population. In fact, two different types of Leu 7+ elements populate the exocrine pancreas: a, Leu 7+ cells showing an intracellular granule positivity; b, Leu 7+ cells showing surface positivity. The endocrine pancreas, in contrast, contains the majority (85%) of Leu 7+ elements, belonging to the intracellular positive type only.

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Mentioned in this Paper

Monoclonal Antibodies
Malignant Neoplasm of Endocrine Pancreas
Entire Endocrine Pancreas
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Science of Morphology
Antigenic Specificity
Benign Tumor of Pancreas

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