PMID: 2492453Feb 10, 1989Paper

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

Cell
M SchuermannR Müller

Abstract

Cellular and viral Fos proteins form a tight complex with other nuclear proteins, including the transcription factor and proto-oncogene AP-1/Jun. We have mapped the c-Jun binding site in Fos to a region containing regularly spaced leucine residues recently suggested to interdigitate with a similar structure in Jun. Substitution of single or multiple leucine residues or the alteration of leucine phasing by insertion of additional amino acids reduces or abolishes the binding to Jun, while the substitution of other amino acids has no noticeable effect. These results strongly suggest that the formation of a "leucine zipper" mediates the interaction between Fos and Jun. We also show that the differential binding of the various Fos mutants correlates with their potential to trans-activate AP-1-dependent transcription and to induce morphological transformation.

Citations

Apr 1, 1990·Journal of Cellular Biochemistry·E A AllegrettoM Karin
Jul 1, 1993·Protein Science : a Publication of the Protein Society·J C HuR T Sauer
Nov 1, 1990·Developmental Biology·F A van der HoornS K Nordeen
Jan 1, 1990·Pharmacology & Therapeutics·H J Rahmsdorf, P Herrlich
Jan 1, 1991·Neurochemistry International·X Liu, K E Vrana
Aug 11, 1995·Molecular and Cellular Endocrinology·B van der BurgP T van der Saag
Dec 11, 1990·Biochimica Et Biophysica Acta·C K Glass, J M Holloway
Jun 1, 1990·Biochimica Et Biophysica Acta·S Goodbourn
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H A Armelin
Mar 12, 1992·European Journal of Pharmacology·P F MorganM Linnoila
Jun 1, 1997·The Annals of Thoracic Surgery·H AebertH Schunkert
May 30, 2001·Progress in Biophysics and Molecular Biology·D Fedida, J C Hesketh
Dec 31, 1996·Brain Research. Molecular Brain Research·F Kamme, T Wieloch
May 10, 2003·Blood Cells, Molecules & Diseases·George B SegelNancy Wang
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M NishizawaS Kawai
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J SchmidtB Burr
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L J RansoneI M Verma
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M R GartenbergD M Crothers
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L AckermanC Y Yeung
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R RasmussenT Alber
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H SchunkertB H Lorell
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K McCormackB Rudy
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C J Kho, H Zarbl
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·A E Menkens, A R Cashmore
Jan 8, 2010·The Journal of Biological Chemistry·Cécile E MalnouIsabelle Jariel-Encontre
Jan 1, 1992·The Journal of Cell Biology·N D RidgwayJ L Goldstein
Aug 1, 1993·The Journal of Cell Biology·A E GrigoriadisE F Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.