The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs

Research in Veterinary Science
J M HansonB P Meij

Abstract

Pituitary dwarfism in German shepherd dogs is characterized by combined pituitary hormone deficiency (CPHD) and intrapituitary cyst formation. Activation of the leukemia inhibitory factor (LIF)-LIF receptor (LIFR) signal transduction pathway results in a similar phenotype in (transgenic) mice. We therefore assessed the role of the LIFR in the etiology of pituitary dwarfism in German shepherd dogs. A polymorphic microsatellite marker (UULIFR) was used to analyze the segregation of the LIFR gene in 22 German shepherd dogs from 4 pedigrees, each including one dwarf. There was no allelic association between UULIFR and the dwarfism phenotype. Based on our findings LIFR was excluded as a candidate gene for CPHD.

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Citations

Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kate L TsaiLeigh Anne Clark
Feb 13, 2008·Equine Veterinary Journal·W BackT A E Stout
Sep 21, 2013·Journal of the American Animal Hospital Association·Kyu-Deok ChoMhan-Pyo Yang

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