The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol-Associated Hepatitis.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jessica A MustoMichael R Lucey

Abstract

The 10-item Alcohol Use Disorders Identification Test (AUDIT-10) and its shorter form, AUDIT-Consumption (AUDIT-C), are questionnaires used to characterize severity of drinking. We hypothesized that liver injury and short-term outcomes of alcohol-associated hepatitis (AH) would correlate with a patient's recent alcohol consumption as determined by AUDIT-10 and AUDIT-C. We analyzed a prospective international database of patients with AH diagnosed based on the National Institute on Alcohol Abuse and Alcoholism (NIAAA) standard definitions. All patients were interviewed using AUDIT-10. Primary outcomes included the discriminatory ability of the AUDIT-10 and AUDIT-C scores for predicting survival status at 28 and 90 days and severity of liver injury, as measured by Model for End-Stage Liver Disease-sodium (MELD-Na). The relationship between AUDIT scores and survival status was quantified by calculating the area under the curve of the receiver operating characteristic analysis. The relationship between AUDIT scores and MELD-Na was examined using correlation coefficients. In 245 patients (age range 25-75 years; 35% female), we found no correlation between AUDIT-10 or AUDIT-C scores and either 28- or 90-day mortality. Similarly, ther...Continue Reading

References

Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R M WeinriebM R Lucey
May 24, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandre LouvetPhilippe Mathurin
Jun 26, 2009·The New England Journal of Medicine·Michael R LuceyTimothy R Morgan
Dec 1, 2009·Nature Genetics·Chao TianDavid A Hinds
May 11, 2011·The American Journal of Gastroenterology·José AltamiranoRamón Bataller
Jun 21, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suthat LiangpunsakulUNKNOWN Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium
May 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandre LouvetPhilippe Mathurin
Jun 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·José AltamiranoAnna Lligoña
Apr 28, 2017·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Spencer LourensUNKNOWN TREAT Consortium
May 3, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thoetchai Bee PeeraphatditDouglas A Simonetto
Jul 18, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David W CrabbMichael R Lucey
Aug 16, 2019·Alimentary Pharmacology & Therapeutics·Kimberly E Daniel, Michael R Lucey

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