The level of MnSOD is directly correlated with grade of brain tumours of neuroepithelial origin

British Journal of Cancer
M LandriscinaT Galeotti

Abstract

The oxy-radical scavenger enzyme manganese superoxide dismutase (MnSOD) may act in the capacity of a tumour-suppressor gene. To address the issue of its role in tumour transformation and progression in vivo, we evaluated the content of this enzyme in 33 brain tumours of neuroepithelial origin with different degrees of differentiation (WHO grade II-IV) by means of Western blot and immunohistology. Our results show that immunoreactive MnSOD increases in a direct relationship with tumour grade and is therefore inversely correlated with differentiation. The increase in induced at a pretranscriptional level and is apparently specific to brain tumours of neuroepithelial origin. Approximately 30% of grade IV tumours display low levels of MnSOD content, and preoperative radiotherapy and brachytherapy result in low amounts of enzyme. Based upon these observations, we suggest that MnSOD cannot be considered a classical tumour-suppressor gene.

Citations

May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·K KahlosV L Kinnula
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·B PalazzottiT Galeotti
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·K JärvinenV L Kinnula
Nov 24, 2004·Drug Metabolism Reviews·Regine KahlYvonni Chovolou
Aug 24, 2013·Antioxidants & Redox Signaling·Alan Prem KumarMarie Veronique Clement
Mar 25, 2004·American Journal of Respiratory Cell and Molecular Biology·Vuokko L KinnulaSakari Knuutila
May 24, 2011·Enzyme Research·Delira Robbins, Yunfeng Zhao
Oct 2, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·R K JainSandeep K Jha
Jul 22, 2018·Metallomics : Integrated Biometal Science·Philip A Doble, George L Gabor Miklos
Sep 26, 2009·Antioxidants & Redox Signaling·Matteo LandriscinaFranca Esposito
Aug 12, 2014·Biochemical Society Transactions·Anja Konzack, Thomas Kietzmann
May 28, 2013·Antioxidants & Redox Signaling·Delira Robbins, Yunfeng Zhao
Apr 17, 2008·International Journal of Cancer. Journal International Du Cancer·Daniel PouliquenJean Menanteau
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Daniel L Pouliquen
Aug 18, 2010·Antioxidants & Redox Signaling·Giovambattista Pani, Tommaso Galeotti
Nov 4, 2017·Antioxidants·Yeon Soo KimNadine Hempel
Mar 3, 2004·Free Radical Biology & Medicine·Vuokko L Kinnula, James D Crapo
May 17, 2011·Free Radical Biology & Medicine·Nirmala ParajuliLee Ann Macmillan-Crow
May 9, 2012·Free Radical Biology & Medicine·Sanjit Kumar Dhar, Daret K St Clair

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