The levels of soluble forms of CD21 and CD83 in multiple sclerosis

Journal of Neuroimmunology
Sajad KarampoorHossein Keyvani

Abstract

Multiple Sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) in which immune system plays a crucial role in progression of the disease. An enormous amount of research has been shown that immune mediators such as cytokines and chemokines are the culprits of MS propagation suggesting that modulation of such molecules may pave the path to hinder the disease development. It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively. Hence, in this study, we measured the serum concentrations of soluble forms of CD21 and CD83 in 255 patients with MS divided into two groups who were receiving interferon-beta (185 MS patients) and fingolimod (70 MS patients) in comparison to 384 healthy individuals. The levels of EBV titers including anti-VCA IgM, anti-VCA IgG and anti-EBNA-1 IgG were also measured. The results showed that the concentration of soluble CD21 (sCD21) was markedly decreased in serum samples of MS patients with respect of controls. Contrarily, the level of soluble CD83 (sCD83) was elevated in MS patient...Continue Reading

Citations

Jun 25, 2019·Frontiers in Immunology·Ziduo LiGeorgina J Clark
May 5, 2020·Frontiers in Immunology·Linda GroscheMatthias Lechmann
Jul 6, 2021·Journal of Neuroimmunology·Rasoul MirzaeiSajad Karampoor

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