The Lewis system and kidney transplantation

Transplantation
R OriolP I Terasaki

Abstract

A significant effect of Lewis antigens on cadaver kidney graft survival was found in 1,300 North American transplants. Lewis-negative recipients had a graft survival rate that was 8% lower than that of Lewis-positive recipients (P = 0.05). This effect of Lewis antigens was enhanced in patients at a high failure risk as determined by age, race, or transplant center. In patients older than 30 years, the effect of Lewis was 14% (P = 0.07), in non-Caucasians 12% (P = 0.07), in all grafts performed at centers with less than 50% overall 1-year graft survival 12% (P = 0.03), and in non-Caucasians that received transplants in centers with less than 50% overall graft survival it was 18% (p = 0.01). These data confirm previous results on the role of Lewis as a histocompatibility system in renal transplantation; furthermore, they demonstrate that the influence of Lewis is larger in patients at high risk.

Citations

Oct 1, 1986·Human Immunology·T MyserM Kennedy
Jul 1, 1988·Journal of Chromatography·S C FrantzT M Phillips
Nov 21, 2007·Transplantation Proceedings·M BoratyńskaM Klinger
Aug 15, 1984·Archives of Biochemistry and Biophysics·M BlaszczykH Koprowski
Jan 1, 1985·The Journal of Surgical Research·C M Zmijewski
Mar 1, 1982·Tissue Antigens·E E EtheredgeC B Anderson
Jul 4, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Stephen G HoltRosemary Masterson

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