The Lieber-DeCarli Diet-A Flagship Model for Experimental Alcoholic Liver Disease

Alcoholism, Clinical and Experimental Research
Feifei GuoYulia A Nevzorova

Abstract

Alcoholic liver disease (ALD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. Understanding the pathophysiology and successful treatment for ALD is closely associated with the suitability of the animal model, which fully reflects all aspects of the pathogenesis and typical histological findings. This study reviews one of the most widely used experimental models of ALD in rodents-the Lieber-DeCarli (LDC) liquid diet. It is an easy, accurate, reliable, and inexpensive model to study the pathogenesis of early stages of ALD. Here, we discuss the historical background and provide an overview of the advantages and disadvantages of the classical LDC as well as modified "second-hit" models. We also provide a comprehensive protocol for the application of the LDC diet to perform it successfully, reliably, and reproducibly in mice.

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Citations

Dec 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Blaine CaslinEsther Melamed
May 14, 2020·Journal of Lipid Research·Jason CorrentiRotonya M Carr
Mar 20, 2020·International Journal of Molecular Sciences·Sandra TorresJonel Trebicka
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Apr 25, 2020·Journal of Hepatology·Yulia A NevzorovaJordi Gracia-Sancho
Mar 27, 2021·PloS One·Monideepa SenguptaColin A Flaveny
Sep 16, 2021·Alcoholism, Clinical and Experimental Research·Michael SchonfeldIrina Tikhanovich
Jan 6, 2022·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mukund P SrinivasanBhupendra S Kaphalia

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