The life cycle of neutral lipids: synthesis, storage and degradation

Cellular and Molecular Life Sciences : CMLS
Karin Athenstaedt, Günther Daum

Abstract

Triacylglycerols (TAGs), steryl esters (SEs) and wax esters (WEs) form the group of neutral lipids. Whereas TAGs are present in all types of cell, the occurrence of SEs in prokaryotes is questionable, and the presence of WEs as storage molecules is restricted to plants and a few bacteria. Here, we summarize recent knowledge on the formation, storage and degradation of TAGs and SEs in various cell types. We describe the biochemical pathways involved in TAG and SE synthesis and discuss the subcellular compartmentation of these processes. Recently, several novel enzymes governing the metabolism of storage lipids have been identified and characterized. Regulatory aspects of neutral lipid storage are just beginning to be understood. Finally, we describe consequences of defects in neutral lipid metabolism. Since severe diseases like atherosclerosis, obesity and type 2 diabetes are caused by lipid accumulation, mechanisms underlying neutral lipid synthesis, depot formation and mobilization are of major interest for curing such diseases that are increasingly associated with modern civilization.

Citations

Apr 6, 2011·Applied Microbiology and Biotechnology·Jose Manuel AgeitosTomas G Villa
Apr 1, 2011·Applied Microbiology and Biotechnology·Athanasios BeopoulosClaude Gaillardin
Jul 1, 2010·World Journal of Microbiology & Biotechnology·Jasminka RupčićBranka Blagović
Aug 13, 2008·The Journal of Biological Chemistry·Neil GrimseySymeon Siniossoglou
Mar 17, 2010·The Journal of Biological Chemistry·Sepp D Kohlwein
Apr 26, 2013·Plant Physiology·Somrutai WinichayakulNicholas John Roberts
Sep 4, 2009·Annual Review of Entomology·Estela L Arrese, Jose L Soulages
Jan 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Aaron R Turkish, Stephen L Sturley
Sep 22, 2011·BMC Evolutionary Biology·Andreia C Turchetto-ZoletRogerio Margis
Jul 30, 2009·Lipids in Health and Disease·Wai Yen Alfred LimSharifah Noor Akmal Syed Husain
Sep 11, 2007·Theoretical Biology & Medical Modelling·Jens Köhler, Bernhard Wünsch
Jan 26, 2012·PLoS Genetics·Xiaojun XuAurelio A Teleman
Jul 21, 2014·Journal of Industrial Microbiology & Biotechnology·Yuan-Yuan LiuZhen-Ming Chi
Feb 26, 2016·Poultry Science·Yong ZhaoZhi-Hui Hao
Jan 7, 2015·International Journal of Molecular Sciences·Chunfa Huang, Carl Freter
Dec 1, 2006·Expert Opinion on Drug Discovery·Markus R Wenk
Jan 2, 2016·Molecular Phylogenetics and Evolution·Ana Paula KörbesAndreia Carina Turchetto-Zolet
Jan 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng LiHao Xu
Jun 19, 2012·Progress in Lipid Research·Qin LiuRandall J Weselake
Aug 13, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Kelvin K W WongV Thiyagarajan
May 31, 2011·Progress in Lipid Research·Ronald P Kühnlein
Dec 15, 2010·Trends in Biotechnology·Matyas Kosa, Arthur J Ragauskas
Mar 19, 2014·Journal of Agricultural and Food Chemistry·Luis A GarayJ Bruce German
Feb 9, 2008·Progress in Lipid Research·Sona RajakumariGünther Daum
Apr 17, 2007·Biochimica Et Biophysica Acta·Timothy A Schulz, William A Prinz
Apr 25, 2007·Chemistry and Physics of Lipids·Eva FalchMarit Aursand
Mar 31, 2007·Biochimica Et Biophysica Acta·Peter Griac
Jun 6, 2009·Traffic·Symeon Siniossoglou
Mar 5, 2011·Maternal & Child Nutrition·J Bruce German
Aug 15, 2015·Microbiology·Tayvich VorapreedaKobkul Laoteng

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