The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate

Experimental Neurology
Elizabeth J DallimoreA R Harvey

Abstract

The extensive period of retinal ganglion cell (RGC) neurogenesis in the rat is associated with a protracted sequence of arrival of their axons into central targets such as the superior colliculus (SC) (Dallimore et al., 2002). Using in utero 5-bromo-2'-deoxyrudine (BrdU) injections to label early (embryonic day (E) 15) or late (E18 or E19) born RGCs, we now show that E15 RGCs with axons that enter the SC prenatally undergo programmed cell death earlier than late-born RGCs whose axons only reach the SC late in the first postnatal week. These late-born RGCs do not begin to die until postnatal day (P) 5/6. Removal of retrograde trophic support by P1 SC ablation initially only affects E15 RGCs; however by P5 death of late-born RGCs is increased, confirming that a switch to target dependency is delayed in this cohort. In a further experiment it was found that, following complete rostral SC transection at P2, the proportion of post-lesion axons originating from E19 RGCs was significantly greater than the proportion that normally makes up the retinotectal projection. Thus, even in neonatal brain, uninjured late-arriving axons are more likely to grow across a lesion site than injured axons undergoing regeneration. To study if birth dat...Continue Reading

References

Jan 1, 1992·Neuroscience·B E Reese, R J Colello
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 15, 1989·The Journal of Comparative Neurology·X M Xu, G F Martin
Sep 22, 1987·The Journal of Comparative Neurology·G M Horsburgh, A J Sefton
Oct 8, 1985·The Journal of Comparative Neurology·A R Harvey, A M MacDonald
Jan 1, 1971·Physiological Reviews·H EliasD E Schwartz
Jul 13, 1972·Brain Research·R D Lund, J S Lund
Jul 17, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V H Perry, M Walker
Sep 21, 1984·Science·W M CowanB B Stanfield
Aug 1, 1983·Brain Research·R Linden, V H Perry
Sep 20, 1983·The Journal of Comparative Neurology·V H PerryR Linden
May 1, 1983·Neuroscience·D J Schreyer, E G Jones
Mar 1, 1982·Brain Research·R A PottsM R Bennett
Nov 1, 1982·The Journal of Comparative Neurology·K Kalil, T Reh
Oct 1, 1980·Journal of Neurocytology·D L GiordanoT J Cunningham
Jan 1, 1994·Progress in Brain Research·G F MartinX C Zou
Jun 1, 1996·Trends in Neurosciences·J Nicholls, N Saunders

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Citations

Dec 29, 2012·Journal of Biomolecular Screening·Djoere GaublommeLieve Moons
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Jamie BerosAlan R Harvey

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