The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types

Development
Feifan ZhangOliver Hobert

Abstract

Transcription factors that drive neuron type-specific terminal differentiation programs in the developing nervous system are often expressed in several distinct neuronal cell types, but to what extent they have similar or distinct activities in individual neuronal cell types is generally not well explored. We investigate this problem using, as a starting point, the C. elegans LIM homeodomain transcription factor ttx-3, which acts as a terminal selector to drive the terminal differentiation program of the cholinergic AIY interneuron class. Using a panel of different terminal differentiation markers, including neurotransmitter synthesizing enzymes, neurotransmitter receptors and neuropeptides, we show that ttx-3 also controls the terminal differentiation program of two additional, distinct neuron types, namely the cholinergic AIA interneurons and the serotonergic NSM neurons. We show that the type of differentiation program that is controlled by ttx-3 in different neuron types is specified by a distinct set of collaborating transcription factors. One of the collaborating transcription factors is the POU homeobox gene unc-86, which collaborates with ttx-3 to determine the identity of the serotonergic NSM neurons. unc-86 in turn op...Continue Reading

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Citations

Jun 16, 2014·Nature Neuroscience·Evan S Deneris, Oliver Hobert
May 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Andreas ZembrzyckiDennis D M O'Leary
Aug 21, 2015·Neuron·Nikolaos StefanakisOliver Hobert
Apr 10, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Douglas W Allan, Stefan Thor
Jun 23, 2015·Developmental Cell·Patricia M Gordon, Oliver Hobert
Jul 8, 2014·Current Opinion in Genetics & Development·Kaia Achim, Detlev Arendt
Feb 25, 2015·Developmental Cell·Heekyung Jung, Jeremy S Dasen
Nov 25, 2014·Cell and Tissue Research·Jovica Ninkovic, Magdalena Götz
May 3, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Oliver Hobert
Nov 2, 2016·Molecular Biology of the Cell·Daniel A Colón-Ramos
Oct 3, 2017·PLoS Genetics·Irini TopalidouMichael Ailion
Jul 18, 2020·Development·Marcin Andrzej LipiecMarta Barbara Wiśniewska
Jul 16, 2020·G3 : Genes - Genomes - Genetics·Albert ZhangDong Yan
Nov 30, 2019·Genetics·Esther Serrano-SaizOliver Hobert
Feb 6, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Eduardo Leyva-DíazOliver Hobert
Oct 2, 2020·Developmental Cell·Julien CharestLuisa Cochella
Jan 1, 2020·Genetics·Esther Serrano-SaizOliver Hobert
Aug 28, 2021·Nature Reviews. Neuroscience·Oliver Hobert

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