The LIM and SH3 domain protein family: structural proteins or signal transducers or both?

Molecular Cancer
Thomas G P Grunewald, Elke Butt

Abstract

LIM and SH3 Protein 1 (LASP-1) was initially identified from a cDNA library of metastatic axillary lymph nodes (MLN) more than a decade ago. It was found to be overexpressed in human breast and ovarian cancer and became the first member of a newly defined LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. LASP2, a novel LASP1-related gene was first identified and characterized in silico. Subsequently it proved to be a splice variant of the Nebulin gene and therefore was also termed LIM/nebulette. LASP-1 and -2 are highly conserved in their LIM, nebulin-like and SH3 domains but differ significantly at their linker regions. Both proteins are ubiquitously expressed and involved in cytoskeletal architecture, especially in the organization of focal adhesions. Here we present the first systematic review to summarize all relevant data concerning their domain organization, expression profiles, regulating factors and function. We compile evidence that both, LASP-1 and LASP-2, are important during early embryo- and fetogenesis and are highly expressed in the central nervous system of the adult. However, only LASP-1 seems to participate significantly in neuronal differentiation and pl...Continue Reading

Citations

May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cathy B MoelansPaul J van Diest
Apr 27, 2010·PloS One·Dayanidhi RamanAnn Richmond
Apr 20, 2012·PloS One·Miriam StöltingJoachim Kremerskothen
Aug 12, 2014·Disease Markers·Timothy Ming-Hun WanRoberta Wen-Chi Pang
Mar 12, 2015·International Journal of Oncology·Alessandro SalviGiuseppina De Petro
Apr 7, 2012·Urologic Oncology·Peter ArdeltElke Butt
Aug 4, 2015·Archives of Gynecology and Obstetrics·S E SegererU Kämmerer
Aug 25, 2009·Translational Oncology·Thomas Gp GrunewaldElke Butt
Jan 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongchen ZhangWei Gong
Oct 19, 2010·Trends in Cell Biology·Christopher T PappasCarol C Gregorio
Sep 17, 2010·Urologic Oncology·Takeshi ChiyomaruMasayuki Nakagawa
Sep 1, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Marie-Louise Bang, Ju Chen
May 26, 2009·Cell Motility and the Cytoskeleton·Carol A OteySilvia M Goicoechea
Nov 8, 2011·Biology of the Cell·Semjon WillierThomas G P Grunewald
Mar 1, 2014·Cell Biochemistry and Function·Hyuck Joon KwonKazunori Yasuda
Jun 21, 2012·Journal of Experimental & Clinical Cancer Research : CR·Chen WangYurong Shi
Oct 19, 2010·Journal of the American College of Cardiology·Enkhsaikhan PurevjavJeffrey A Towbin
Jul 29, 2008·Mechanisms of Development·Soojin LeeFrieder Schöck
Mar 6, 2013·Journal of Proteome Research·Susan FanayanEdouard Nice
Jan 18, 2017·Journal of Cellular Physiology·Phil-Sun OhHwan-Jeong Jeong
Oct 14, 2017·Journal of Cell Communication and Signaling·Elaine NganPeter M Siegel
Jan 31, 2019·PloS One·Artur GurgulMonika Bugno-Poniewierska
Apr 27, 2019·Journal of Cellular Biochemistry·Yimeng Zhang, Liya Zhang
May 24, 2011·Reproduction in Domestic Animals = Zuchthygiene·C C HsuS T Ding
Nov 1, 2017·Oncology Letters·Misaki SatoShigeru Tsuboi
Nov 16, 2017·International Journal of Oncology·Jianguang ShiXinjian Li
Aug 2, 2020·Journal of the American Society of Nephrology : JASN·Xuhua GeEvren U Azeloglu
Jul 17, 2020·Disease Markers·Xiaojing YangJie Fu

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
two-hybrid
fluorescence recovery after photobleaching
GTPase

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.